You had already highlighted them: An interesting thing was that the findings with the MRI were consistent over time but not with the SPECT scans - some people with the latter had them on the first time but not the second test and vice versa. It also made clear that the definition of abnormality they used was somewhat arbitrary and another paper had used a different definition. Also the locations for the abnormalities in the second paper were similar to the depression cohort. These were authors who did say the abnormalities suggested a biological process. Anyway, I'll need to see more evidence to see how good they are in M.E. specifically. For example, I had relatively mild M.E. for the first few years - would it have shown up I wonder.