Hi everyone. After trying numerous approaches to figure out what's going on with my CFS, I went to see a rheumatologist and had a ton of bloodwork done. Saw her on Monday and the ONLY things that showed up were low C3 and C4 complements. But they were low, which is encouraging since it indicates there's an inflammatory something going on in my system. I've also been dealing with dry mouth and eyes, so between those results and my clinical signs, she diagnosed me with Sjogren's (she has an affiliation with the Sjogren's Center at University of Pennsylvania, so I trust that she knows what she's looking at). I do have a couple of questions that I thought I'd pose here - hopefully someone has some information. First, I started on Plaquenil Monday evening, one 200 mg tab twice a day. Can anyone who's been on this med tell me how long before you started to feel any positive effects? I did a little web surfing and it sounds like it could be a slow climb out of the hole, possibly several months. Just want to know if I really do need to be patient (yeah, six and a half years without a diagnosis...I suppose I can hang on for a few months). Second, and oddly, the antibody tests for Sjogren's (SSA and SSB) were both negative. I believe that means I have secondary Sjogren's, i.e., it's secondary to something else....which also means I may only be halfway towards an effective treatment. Does anyone know if it's possible to get a diagnosis of primary Sjogren's with these two test results being negative? I need to call my doctor next week (I just started worrying about this last night), but if anyone has thoughts on this, I'd welcome your opinion. Many thanks, as always. Even though I haven't posted much, this is a tremendous resource for me.