DHEA has important benefits on oxidative energy metabolism as well as modulating cortisol. It also increases levels of glutamate dehydrogenase. Glutamate is often elevated and neurotoxic due to activated microglial cells. DHEA is also an antioxidant and may stimulate neurogenesis. While too much is also not a good thing, leaving levels low for long periods of time seems counterproductive at best as well. I supplement DHEA at 25 mg a day; men can often use up to 50 mg/day successfully. Optimal DHEA levels may be considered to be in the 4-500 ug/dl range for men and 350-430 for women.