Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
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dextromethorphan/fibro/reduce benzo tolerance???

Discussion in 'General Treatment' started by heapsreal, Jul 13, 2012.

  1. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    Hi,
    While surfing the net i come across how dextromethorphan(DXM) has helped people with fibro pain which i have read about before but then came across how some people are using DXM to reduce benzo tolerance. Reducing benzo tolerance info is mainly anecdotel, people came across it by accident when they took the dxm in a cough medicine and then took there normal benzo for sleep and it improved the effectiveness of the benzo's. Many seem to think that it reduce the tolerence and can use even lower doses with good effect. Also seems to work for narcotic pain relief as well, the benefits have been that people get use lower doses and they are just as effective as higher doses.

    DXM is suppose to have NMDA antagonist properties and this is supposedly the mechanism that helps fibro pain as well as reducing drug tolerance. Dosages seem to vary and some info is from people who are only interested in getting high, but if they have useful information that helps us treat our condition better then im cool with that. My understanding is that it is a safe drug when used in normal doses and is sold over the counter as a cough medicine.

    I think this is an interesting med to look into especially the subject of benzo tolerance which has been in alot of threads of late. Reducing the dose of meds to the least amount thats effective i think is a good thing.

    Heres some links http://www.fibromyalgia-symptoms.org/fibromyalgia_dextromethorphan.html
    http://www.webmd.com/fibromyalgia/news/20050523/cough-drug-may-help-fibromyalgia-pain
    http://www.drugs-forum.com/forum/showthread.php?t=159644

    I would like to know if anyone has used this dmx for pain or other purposes.

    cheers!!!
     
  2. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    Combined oral administration of morphine sulfate (MS) and the over-the-counter antitussive drug and N-methyl-d-aspartate receptor antagonist dextromethorphan (DM) prevented the development of tolerance to the antinociceptive effects of MS (15, 24, or 32 mg/kg) in rats. This combined oral treatment regimen also attenuated signs of naloxone-precipitated physical dependence on morphine in the same rats. A wide range of ratios of MS to DM (2:1, 1:1, and 1:2) were effective for preventing the development of morphine tolerance and dependence. In addition, we provide evidence that under certain circumstances DM increases the acute antinociceptive effects of MS. All of these results indicate that oral treatment that combines DM with opiate analgesics may be a powerful approach for simultaneously preventing opiate tolerance and dependence and enhancing analgesia in humans.

    http://www.sciencedirect.com/science/article/pii/030439599603120X
     

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