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Detection of Urine Metabolites in a Rat Model of Chronic Fatigue Syndrome before and after Exercise

Discussion in 'Latest ME/CFS Research' started by Kati, Apr 20, 2017.

  1. CFS_for_19_years

    CFS_for_19_years คภภเє ɠรค๓թєl

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    Forced swimming has also been used as a rat model to replicate CFS. Here's another discussion of a study using rats:
    http://forums.phoenixrising.me/inde...n-chronic-fatigue-syndrome.47204/#post-771223

    See what came up on a search of PubMed:
    https://www.ncbi.nlm.nih.gov/pubmed/?term=cfs rats forced swimming:

    A Chinese herbal decoction, Danggui Buxue Tang, improves chronic fatigue syndrome induced by food restriction and forced swimming in rats.

    Astragalus membranaceus flavonoids (AMF) ameliorate chronic fatigue syndrome induced by food intake restriction plus forced swimming.

    Effect of manual acupuncture stimulation of "Baihui" (GV 20), etc. on serum IFN-gamma and IL-4 contents in rats with chronic fatigue syndrome

    Effect of acupuncture intervention on learning-memory ability and cerebral superoxide dismutase activity and malonaldehyde concentration in chronic fatigue syndrome rats

    Effect of natural and synthetic antioxidants in a mouse model of chronic fatigue syndrome

    Evaluation of protective effect of Aegle marmelos Corr. in an animal model of chronic fatigue syndrome
     
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  2. JaimeS

    JaimeS Senior Member

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  3. CFS_for_19_years

    CFS_for_19_years คภภเє ɠรค๓թєl

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    At least they now have a model for giving acupuncture to over-exercised rats. At least it sounds sciencey.
     
  4. HowToEscape?

    HowToEscape? Senior Member

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    Exactly: that army training was surely 100 times more intense than what the rats got.

    Pretty cool job I must say, far beats cubicle drone camp.
     
  5. IreneF

    IreneF Senior Member

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    The forced swim test is used to see if rats are depressed. You plop them into a deep pool of water and time how long it takes them to give up.
    https://en.m.wikipedia.org/wiki/Behavioural_despair_test
    Needless to say, there are a lot of problems with this test.
     
  6. Murph

    Murph :)

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    This model does seem bad. But I can't dismiss it entirely since it yielded a sphingolipid result. Perhaps it manages to replicate some of the important features of CFS? After all, that's all a model is: a set of useful features. I'd want to know more.

    As for making a more plausible model. It might be interesting to get rats, exercise them hard then hit them with a virus and see if a proportion never quite recover. That is an experiment I'd like to see.
     
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  7. RogerBlack

    RogerBlack Senior Member

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    Also, a noninvasive test, such as a urine test is of course better than blood, if it works, and applied to CFS.
    An objective measure of fatigue, even if it wasn't CFS fatigue in urine would perhaps be useful as an objective measurement for trials, or even home monitoring.
     
  8. Snow Leopard

    Snow Leopard Hibernating

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    Yes, down to the choice of rock music.
     
  9. IreneF

    IreneF Senior Member

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    If hard exercise induced CFS then army recruits and athletes would be in for it. And, in fact, military installations are good places for diseases to spread.
     
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  10. CFS_for_19_years

    CFS_for_19_years คภภเє ɠรค๓թєl

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    As someone who trained hard as a competitive swimmer in college while living in a crowded dormitory that housed several other swim team members, I don't recall that any one of us came down with ME/CFS. At least I didn't until 17 years later. So :p to their silly model of exercising rats.
     
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