Phoenix Rising supports the Millions Missing global day of protest
Phoenix Rising is delighted to support the demands being made in the ME/CFS community’s first-ever global day of protest …
Discuss the article on the Forums.

Detection of Urine Metabolites in a Rat Model of Chronic Fatigue Syndrome before and after Exercise

Discussion in 'Latest ME/CFS Research' started by Kati, Apr 20, 2017.

  1. CFS_for_19_years

    CFS_for_19_years Hoarder of biscuits

    Messages:
    1,980
    Likes:
    5,023
    USA
    Forced swimming has also been used as a rat model to replicate CFS. Here's another discussion of a study using rats:
    http://forums.phoenixrising.me/inde...n-chronic-fatigue-syndrome.47204/#post-771223

    See what came up on a search of PubMed:
    https://www.ncbi.nlm.nih.gov/pubmed/?term=cfs rats forced swimming:

    A Chinese herbal decoction, Danggui Buxue Tang, improves chronic fatigue syndrome induced by food restriction and forced swimming in rats.

    Astragalus membranaceus flavonoids (AMF) ameliorate chronic fatigue syndrome induced by food intake restriction plus forced swimming.

    Effect of manual acupuncture stimulation of "Baihui" (GV 20), etc. on serum IFN-gamma and IL-4 contents in rats with chronic fatigue syndrome

    Effect of acupuncture intervention on learning-memory ability and cerebral superoxide dismutase activity and malonaldehyde concentration in chronic fatigue syndrome rats

    Effect of natural and synthetic antioxidants in a mouse model of chronic fatigue syndrome

    Evaluation of protective effect of Aegle marmelos Corr. in an animal model of chronic fatigue syndrome
     
    JaimeS likes this.
  2. JaimeS

    JaimeS Senior Member

    Messages:
    3,159
    Likes:
    11,588
    Mid-Ohio Valley, United States
  3. CFS_for_19_years

    CFS_for_19_years Hoarder of biscuits

    Messages:
    1,980
    Likes:
    5,023
    USA
    At least they now have a model for giving acupuncture to over-exercised rats. At least it sounds sciencey.
     
  4. HowToEscape?

    HowToEscape? Senior Member

    Messages:
    432
    Likes:
    543
    Exac
    Exactly: that army training was surely 100 times more intense than what the rats got.

    Pretty cool job I must say, far beats cubicle drone camp.
     
  5. IreneF

    IreneF Senior Member

    Messages:
    1,550
    Likes:
    2,551
    San Francisco
    The forced swim test is used to see if rats are depressed. You plop them into a deep pool of water and time how long it takes them to give up.
    https://en.m.wikipedia.org/wiki/Behavioural_despair_test
    Needless to say, there are a lot of problems with this test.
     
  6. Murph

    Murph :)

    Messages:
    391
    Likes:
    2,135
    This model does seem bad. But I can't dismiss it entirely since it yielded a sphingolipid result. Perhaps it manages to replicate some of the important features of CFS? After all, that's all a model is: a set of useful features. I'd want to know more.

    As for making a more plausible model. It might be interesting to get rats, exercise them hard then hit them with a virus and see if a proportion never quite recover. That is an experiment I'd like to see.
     
    CFS_for_19_years likes this.
  7. RogerBlack

    RogerBlack Senior Member

    Messages:
    857
    Likes:
    2,781
    Also, a noninvasive test, such as a urine test is of course better than blood, if it works, and applied to CFS.
    An objective measure of fatigue, even if it wasn't CFS fatigue in urine would perhaps be useful as an objective measurement for trials, or even home monitoring.
     
  8. Snow Leopard

    Snow Leopard Hibernating

    Messages:
    4,611
    Likes:
    12,422
    South Australia
    Yes, down to the choice of rock music.
     
  9. IreneF

    IreneF Senior Member

    Messages:
    1,550
    Likes:
    2,551
    San Francisco
    If hard exercise induced CFS then army recruits and athletes would be in for it. And, in fact, military installations are good places for diseases to spread.
     
    CFS_for_19_years and Valentijn like this.
  10. CFS_for_19_years

    CFS_for_19_years Hoarder of biscuits

    Messages:
    1,980
    Likes:
    5,023
    USA
    As someone who trained hard as a competitive swimmer in college while living in a crowded dormitory that housed several other swim team members, I don't recall that any one of us came down with ME/CFS. At least I didn't until 17 years later. So :p to their silly model of exercising rats.
     
    Valentijn and ukxmrv like this.

See more popular forum discussions.

Share This Page