I first posted on this site a year and a half ago. http://forums.phoenixrising.me/index.php?threads/deplin-so-confused.27393/ I have severe anxiety/ocd/depression/racing thoughts I would like to thank everyone for all of their help, especially @caledonia @Freddd @Critterina @Sherpa - I also appreciate your time I had gotten off anti depressants and started to learn about my health. I spent thousands on extensive tests and doctors. Therapy doesn't work and antidepressants don't work. I have tried tons of each for years. I started out being deeply cynical about Big Pharma and most drs, but naturopathy and holistic medicine hasn't helped me either. I don't know if anything can Then I heard about methylation. It is so complex that I went to see a doctor that I got off a MTHFR list. I don't know if it is "ethical" to name him or not, but despite being on that list and having a methylation video on youtube, he didn't seem to know much about methylation. He didn't even give me any b12 other than what was in a b complex that he gave me. No sublinigual and no shots. Later I called Tim Jackson. He seemed knowledgable, but he wasn't a good fit. Again, I don't want to disparage anyone in this forum. I need a doctor that I can work with that is knowledgable. I can't afford to spend tons of money on docs that aren't any more knowledgable than me or people on this forum. I can't afford enless supplements and tests. I also get very anxious when it turns into "you can't eat anything (gluten, dairy, animal proteins, sulfur foods, etc etc)" "you need these 30 tests and take these 50 pills" The other complication is that I live in NY .... the land of tests not available. I don't know how to get around this. Yasko and Ben Lynch don't do consults. Sterling Hill no longer does as of earlier this year. Who else knows their stuff? I searched mthfr.net , mthfrsupport and seeking health. I found docs and checked their websites etc to try and find the "best" There seems to be no consensus on what b12 I should take (methyl/adeno/hydroxy). There are so many contradictions. Some say adeno is good and hydroxy is bad. I don't even know which methylfolate to take. Then there is the matter of cofactors and minerals and other vitamins and electrolytes etc..... I know that I should avoid folic acid (strange that Yasko's all in one has it in it). I don't know how strict that I have to be about avoiding it. I don't go out of my way to take it, but it is in everything!!!! It is hard enough to have lifelong depression without having to avoid pizza and bread and pasta and rice completely. I also hear people saying to take niacin (not just when having a reaction), which I don't understand as it seems to do the opposite of what I want. A post that someone posted in another thread: "I just had doctor try and put me on Niacin - Dear God ! Just one dose of Niacin is enough to send me into the hospital. Niacin is a Methyl Sponge!Â Niacin also plays a role in the COMT SNP - and it can dump lithium. Then if a Doctor puts you on L-Dopa supplements - with COMT gene he better have BH4 onboard." http://forum.jackkruse.com/index.ph...s-your-doctors-knowledge-of-methylation.5152/ That kind of stuff makes me soooo nervous and anxious and overwhelmed I KNOW THAT IT IS NOT ALL ABOUT MTHFR AND THAT OTHER SNPS ARE IMPORTANT. I KNOW THAT BH4 HAS TO BE AN ISSUE AND I KNOW THAT I HAVE AWFUL GENES AS FAR AS MENTAL HEALTH.