My M.E feels like a rheumatic disorder, I have varying degrees of injuries which limit how much/what activity I can do. My knees and ankles are so bad I'm bed bound. If I exceed my limitations not only does it induce pain but it permanently worsens the area I used, for example wrists, knees, or ankles. The threshold for further injury is permanently lowered, so I become brittler – it's a vicious cycle. In my legs the worse of the pain is delayed. I don't really get PEM or flu like symptoms, consequences are very localised not all over. My voice is not excluded and I haven't been able to talk without excessive pain since late 2014. The injuries don't prevent movement and I don't have an obvious limp, but as explained forcing activity worsens the pain and lowers injury threshold. My leg muscles are easily fatigued and build up of lactic acid happens fast. I still have many secondary symptoms, sleep disturbance, cognitive dysfunction, memory issues, sensory issues, etc Has anyone had experience with anything like this? Can you recommend any tests or treatments? @Jonathan Edwards I believe M.E is a heterogeneous disorder with different types.