Cort has written this excellent piece, including some huge tidbits on t-cell research from Unutmaz. https://www.healthrising.org/blog/2017/12/09/me-cfs-researcher-patients-shine-nih-call/ it is way more interesting than the title suggests.... The next five paragraphs are excerpts of Cort's blog post. in response to a great question during the Q&A period, Unutmaz revealed that the most provocative findings found were in the T-cells, and that the findings have proved to be highly reproducible – something we’ve rarely seen outside of NK cells (cousins, it should be pointed out, to T-cells) – in the immune field in ME/CFS. the T-cell abnormalities Unutmaz is finding are associated with the gut probably made Mady Hornig and Ian Lipkin – champions of the role that the gut may play in ME/CFS – smile. It turns out that the problematic T-cells Unutmaz is finding regulate gut functioning. Either something in the guts of ME/CFS patients is messing with the regulatory T-cells or the gut T-cells are simply sitting down on their job. Either way, Unutmaz’ findings appear to put an enhanced focus on the gut in ME/CFS. he gut is a terribly complex place, but with more and more research focusing on it and new methods being developed to understand it, a central problem in the gut might not be a bad thing at all to find in ME/CFS. Unutmaz echoed that hope when he stated that much is known about the cells he’s finding problems in and many treatments are under development to deal with them. That’s very good news for a disease that’s seemed particularly good at featuring issues with cells about which not much is known. Unutmaz said he’ll be following up his T-cell study with a deep and rigorous probe of the gut bacteria in ME/CFS. He won’t just determine which bacteria are there – he’ll actually stress ME/CFS patients to see how their gut bacteria react. His studies will generate a lot of data; the challenge with them, as with all “omics” studies, will be to separate the wheat from the chaff. Unutmaz is also working with Precisely to develop an app to collect clinical data worldwide on ME/CFS patients. We’ve heard of projects like this before, but this may be the first one that has the funding to come to fruition.