I am in a bit of a bind. Low dose naltrexone is by far the best thing to ever happen to my ME. It is the only thing I have ever used that simply works. The change since I have started taking it has been astonishing. However the good effects of the naltrexone appear to keep wearing off, and as a result I have to keep increasing the dose. As I do this is becoming apparent that the naltrexone is causing me depression. My mood is increasingly toxic. I have started once again to brood over long-lost relationships. I'm sick of the sight of parents. I don't want to talk to anyone. Yesterday I burst into tears after hearing something that wasn't even remotely sad. I have never had depression before. Now that my health is improving so much it is a surprise that I am experiencing it now. I can only attribute it to the naltrexone. What do others think of this?