The 12th Invest in ME Research Conference June, 2017, Part 2
MEMum presents the second article in a series of three about the recent 12th Invest In ME International Conference (IIMEC12) in London.
Discuss the article on the Forums.

Depression May Be Caused by Inflammation

Discussion in 'Cognition' started by minkeygirl, Feb 19, 2015.

  1. minkeygirl

    minkeygirl But I Look So Good.

    Messages:
    4,678
    Likes:
    4,639
    Left Coast
  2. anciendaze

    anciendaze Senior Member

    Messages:
    1,769
    Likes:
    4,477
    "Inflammation" is another extremely broad term which can result from a wide range of etiologies. I'm interested in going beyond this.

    A recent post elsewhere concerned a Facebook post by Maryann Spurgin. I've seen a copy, even though I don't use Facebook. It concentrates on yet another weird systemic problem prevalent in ME/CFS, circulatory disorders falling short of normal standards for clinical disease. I could add the comment that every cardiologist is aware that depression goes along with heart disease, just as every psychiatrist is aware that depression regularly follows "flu-like" infections. Neither specialty has felt motivated to go much farther than these observations.

    At one time I went looking through medical literature for possible etiologies for both diastolic dysfunction and less localized circulatory impairment. This led me to consider research on endothelial dysfunction, particularly those papers with clues to possible etiology. What I found were reports from pathologists describing invasion of endothelial tissues by CD8+ T-cells. This was interesting to me, because I had also seen reports of neurological impairment, particularly in the more accessible parts of the nervous system affecting autonomic function, which indicated ganglia were being invaded by CD8+ T-cells. A final aspect of this coincidence is that research on endocrine disturbances leading to GWI found a surprising number of cases of pituitary hypophysitis. (I hope I don't need to tell anyone here that symptoms of GWI are strikingly similar to ME/CFS.) Looking up causes there also led to reports of CD8+ T-cells invading the pituitary. Three very mysterious manifestations of ME/CFS all could be results of immune response about which the IOM report is largely silent.

    This could mean there is an undetected viral infection behind these problems, or it could mean we have an autoimmune response in the cellular immune system. These two categories are not exclusive, because it is definitely possible for immune cells to be infected. Reports of illness resolving after cancer treatment which depleted a specific class of immune cells support either hypothesis. For the subset of patients who repeatedly present with active EBV infections there is even a report of successful treatment using adoptive immunotherapy which stimulates and cultures cytotoxic T-cells outside the body to destroy a very specific subset of immune cells which might either be infected or involved in a malfunctioning immune response.

    Savoldo, B., Huls, M. H., Liu, Z., Okamura, T., Volk, H. D., Reinke, P., ... & Rooney, C. M. (2002). Autologous Epstein-Barr virus (EBV)___specific cytotoxic T cells for the treatment of persistent active EBV infection. Blood, 100(12), 4059-4066.
     
    Valentijn and melamine like this.
  3. Hip

    Hip Senior Member

    Messages:
    8,882
    Likes:
    13,120
    Psychiatry has yet to fully appreciate the studies indicating immune activation (Iinflammation) can lead to mental conditions such as depression, anxiety or schizophrenia.

    You can certainly go beyond, and look for the cause of the inflammation that induces these mental symptoms. And the cause may well be linked to infectious pathogens in many cases.

    I am just happy to see that the link between the immune system and mental or cognitive symptoms is gaining traction.
     
  4. MeSci

    MeSci ME/CFS since 1995; activity level 6?

    Messages:
    7,889
    Likes:
    12,474
    Cornwall, UK
    Just come across a couple of scientific papers on this subject:

     
    Sidereal likes this.
  5. MeSci

    MeSci ME/CFS since 1995; activity level 6?

    Messages:
    7,889
    Likes:
    12,474
    Cornwall, UK
    HIV is of course an example of a virus that infects - and destroys - immune cells.
     
  6. anciendaze

    anciendaze Senior Member

    Messages:
    1,769
    Likes:
    4,477
    So does HTLV-1, it is just much slower and less lethal.
     

See more popular forum discussions.

Share This Page