MAJOR UPDATE: see last post I've been on LDN since July. And am currently up to 5ml. I can't say I've noticed any effect whatsoever. My CFS/ME doc is convinced it's because my immune function is so poor and until I get my immune function improved through K-PAX and a variety of other supplements, it may not work for me. She also wants me to continue to increase the dose because they've had many patients respond at higher doses than the usual 4.5. I'm trying not to but I keep reading so many amazing stories on here of how LDN changed people's lives and it's hard to not feel discouraged and upset that it doesn't seem to be working for me. Dr Klimas seems to think it's going to end up being the standard treatment for CFS/ME too so what do I do if it doesn't work for me?