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Deplin vs Methyl folate

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by helios, Feb 26, 2014.

  1. helios

    helios

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    Brisbane
    I am doing Fredd's protocol. I was the type of responder that felt good initially then started to feel worse. I dialled back the amounts and felt not so bad, but naturally I want to increase them over time to make the protocol worthwhile. I had a little break recently from the supps, and had to admit I felt better for it. I decided to play around a little now and just take methyl folate. With the day, I had sore muscles, sore eyes, teeth felt a little sore, felt a little more lacklustre and got myself a big headache on 2 lots of400mcg. I also took some potassium in the afternoon. Similar sort of reaction I had in the past when I first jumped on methyl folate and took 400-800mg.

    Okay so here is my question. the drug/medicated food supplement Deplin which is prescribed to many people with depression or mental health issues is basically methylfolate. It contains 7500mcg. Reading numerous threads on users experiences with this supplement, I don't see much in the way of negative symptoms experienced by the users, and these people are taking significantly greater amount then many of the people on this forum. What I usually read is that for some Deplin makes no difference and for many its makes a huge difference for the better to their mental well being. Quite a few of these people had genetic testing done which supported they had the MTHFR polymorphism and why they felt so much better on it. I don't understand how this supplement which is a very high dose of 5-mthf (and expensive) can result in so many clear cut outcomes within a very short period of time too for these mental health issue people, yet for lots of folks here its a drama to take.....on a fraction of the dose!
    Why isn't Deplin resulting in all the nasty symptoms people incur here when they kick start the methylation cycle? (some do get symptoms which I recognize as low potassium though)
  2. adreno

    adreno 3% neanderthal

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    Tundras of Europa
    Because those other people don't have ME/CFS.
    Sushi and PeterPositive like this.
  3. helios

    helios

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    Thats what came to mind initially for me. I have had a lot of problems with chemical sensitivities which I assumed was a problem with my methylation cycle and was something I hoped would disappear though they are not as bad as they used to be when I was younger. These people who get prescribed Deplin many have had depression & anxiety & mood disorders for a lot of their life reading some of their stories.They feel like they did 20 yrs ago with a week of taking Deplin. (7.5-15mg/day) they have obviously been suffereing from a defect in methylation for a long time like lots here too, but dont have any of the detox problems from 5-mthf, yet had mental problems relating to it which cleared up quickly. Their mental issues resolve in a week or two. So if its so easy for them on deplin, then methylation is an issue but only just one little piece of the puzzle then for us. Some threads on here treat it like it is a huge piece of the puzzle for many here. I appreciate what you are saying but just dont know if it is that simple....maybe.
    Star-Anise likes this.
  4. shah78

    shah78 Senior Member

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    st pete , florida
    I think about this question(s) every single day. Thanks for starting the thread. Methylation was a huge "piece of the puzzle" for me, but I take doseages on your level. So I'm a member off both groups. A good problem to have, but even more confusing than your situation. I've spend the entire post startup period(frome day 3)trying to take less stuff, because the b12 puts me to sleep during the day.I work around it, because I get four stepes forward vs one step back, but I constantly dreamof taking three steps forward with no step back. Reading about these huge numbers of mcgs people take is mindbending for me. I'm down to 600 mcg. of b9 and 366mcg of mb12 and 400 mcgs of ab12. and I'm moving in the lower direction. Keep bumping this thread until we get some answers/theories.
    Star-Anise likes this.
  5. PeterPositive

    PeterPositive Senior Member

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    Same thing for me and same questions. Given that 1200mcg of sublingual methylfolate can activate an incredible amount of anxiety and irritability, I wouldn't dare to even touch a Deplin pill :D

    Strangely oral metafolin doesn't do that. I can take 1200mcg with no effects whatsoever while 800mcg of sublingual Quatrefolic already stimulates anxiety, although manageable. I guess it's related with digestion/absorption issues.

    I prefer to listen to how my body reacts than to the anxiety of getting results.
    Star-Anise likes this.
  6. shah78

    shah78 Senior Member

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    st pete , florida
    @ adreno. If my reaction to b9/b12 was so sudden, Do you think I actually have/had CFS? and not just a methylation defect? I staqrted my Fredd protocol ass backward. I was up to 2000 mcg. folate for three weeks before starting mb12. The folate did very little to me oneway or another. The only positive, I was more anobolic after the gym, the only negative, I felt like I had polllen alergies. The M12 and ab12 hit like a rock., 80% GOOD. perhaps this is why I pissed you off last week. lol. Maybe I never had thirty years of cfs? I just had a methylation issue?
  7. adreno

    adreno 3% neanderthal

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    I believe CFS is a wastebasket diagnosis. What my point was, is that we all here have chronic illness in some form or another, and that's the reason we react negatively to these supps. I don't think you can diagnose whether you have CFS or not based on your reaction to methyl supps.

    CFS is a clinical diagnosis, meaning that one doctor can decide that you have it, while another can decide that you don't. Ultimately only you can decide whether this diagnosis is useful to you or not. A diagnosis is only useful to me if it can guide me towards effective treatment, otherwise it's just a label.

    I don't have a CFS (or any other) diagnosis, but I take part in discussions here because my cluster of symptoms match closely with others here. I don't find it very useful to ponder whether I should have the CFS label or not. I'm a pragmatist and interested in solutions.
    Last edited: Feb 26, 2014
    whodathunkit, Sea, Sushi and 4 others like this.

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