The power and pitfalls of omics part 2: epigenomics, transcriptomics and ME/CFS
Simon McGrath concludes his blog about the remarkable Prof George Davey Smith's smart ideas for understanding diseases, which may soon be applied to ME/CFS.
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demeirleir

Discussion in 'XMRV Research and Replication Studies' started by ladybugmandy, May 27, 2010.

  1. ladybugmandy

    ladybugmandy

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    Referat fra Prof. De Meirleir
    og Dr Petersons XMRV-foredrag

    i Madrid 26.05

    Rutt @ 14:50

    *Yesterday we have gone to Madrid to hear Dr. Dan
    Peterson's lecture.

    It was an all morning session about XMRV, and the
    first to talk was Dr. Dan Peterson. He shared with
    everybody some of the findings in XMRV (nothing
    new) with many references to Dr. Judy Mikovits and
    the WPI, and his slides were the same that Dr.
    Mikovits uses in her lectures. The reasons for leaving
    the WPI were more a personal decision in order to
    have more time for himself after 25 years of service
    in WPI. He seems to be having a nice rest and is
    very happy to have the time to go sailing again.

    At some point It was mentioned by Daniel Peterson,
    that so far the best biomarker for CFS is the Low
    NKCell function test, and that if your budget was
    restricted, this would be the test to do, I guess He
    was referring to the same direction than Dr. Klimas
    is always talking about as well. http://bit.ly/cJ7YVc

    The second lecture was from Dr. Kenny De Meirleir,
    very interesting, focused on the fact that the most
    important thing now is to have a simple and good
    XMRV Test for all the researchers. He assured that
    they already have the test and it works, and it is a
    matter of days that they will make it available, 3 to
    4 weeks probably.

    De Meirleir also talked about all the work that is
    being done and possible treatments, but curiously
    never mentioned the Ampligen. Dr. Marc Fremont's
    lecture was very technical about this test, and
    finally, Dr. Chris Roelant talked about the urine test
    they already have, which indicates intestinal
    dysbiosis is present in these patients.

    Some of the questions posted in the Conference
    were regarding the recent German study, and the
    fact that XMRV is 3 times more present in immune
    compromised patients already tells you that there is
    an immune problem on CFS patients where most of
    them have the retrovirus.

    There are three pathways affected on CFS which
    affect muscles and CNS:

    25-A
    PKR
    NO

    There are also 3 pats of the immune system
    affected:

    Th1 Linked to viral reactivation and intracellular
    infection due to an excessive hypersensitivity
    Th2 Linked to pathogens, allergies and inflammation
    and blood brain barrier dysfunction
    Th17 Linked to autoimmunity and inflammation and
    blood brain barrier dysfunction

    De Meirleir elaborated later on that Th2 imbalance
    that causes diseases such as CFS, Autism, HIV, MCS,
    Mercury exposure, Allergies, Parasites.
    Th1 relates to cell-based immunity Th2 relates to
    Humoral immunity

    You can see a bit on the conference in this link:

    http://www.youtube.com/watch?v=ywLnptBQLeg

    When we asked Daniel Peterson to comment on Dr.
    Hubert lecture of last Monday in London, his answer
    was that Huber had positives 17 of the 19 samples
    that were sent to her, but She only spoke of the
    samples of other doctors who have tested negative.
    Daniel Peterson has said that once again we face the
    uncertainty of correctness in the samples tested, but
    also added that if She would have done a good job,
    She could not have all negatives, at least 3% would
    be positive, as we see is happening with the recent
    German study.

    When we asked about the fact that HIV patients that
    are XMRV positive and have CFS, are not reacting to
    their current antiretroviral treatment, and that could
    lead to the possibility that XMRV is just a passenger
    virus in a depressed immune system, his answer was
    that actually that would be one possibility, and the
    other one is that they are taking the wrong drug,
    because XMRV is a different retrovirus, and they are
    being treated for HIV.

    When we asked about the German study, and the
    fact that XMRV has been found now in the respiratory
    tract, and that could lead to new ways to detect
    XMRV different from the ones used in WPI, He said
    that is a big possibility. As we know blood is not the
    reservoir of XMRV, maybe the brain or the liver

    There were some other questions regarding the
    prevalence of CFS in children, banning blood
    donations, etc

    I will try to add the whole Conference next week if I
    have the time to do so, but basically these would be
    the headlines of the Conference.*
     
  2. Rivotril

    Rivotril Senior Member

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    Thank you for these headlines! Interesting that Huber tested Peterson's samples positive without mentioning. Or maybe a "move" from her to set up a contamination thing (Kuppeveld also told that he tested a WPI sample positive)
    And good news about the upcoming test!
     
  3. Athene

    Athene ihateticks.me

    Messages:
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    Italy
    Thank you very much for this!
    Please add the rest if/when you can!.
    xxx
     
  4. bluebonnet

    bluebonnet

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    Many thanks!
     
  5. sunlady

    sunlady Guest

    Great post, thankyou.
     

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