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Deficient EBV-Specific B- and T-Cell Response in Patients with Chronic Fatigue Syndrome

Discussion in 'Latest ME/CFS Research' started by Ecoclimber, Jan 16, 2014.

  1. alex3619

    alex3619 Senior Member

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    Logan, Queensland, Australia
    Most of these are long term human pathogens (HIV is an exception). They co-evolved, with humans and other viable species as hosts. We are the environment they co-evolved in. As such it can be expected that they will have capacity to take advantage of other co-infections they have co-evolved with.

    Occam's Razor is about simpler hypotheses having preferences. Its not a law, its a heuristic. Further, I think it was once said (Albert Einstein?) that explanations should be as simple as necessary, but no simpler. In other words, they must explain all the relevant data, and as new data is found that violates them then even more complex hypotheses should be adopted. Biological findings are not set in stone, and even long-standing findings should be considered changeable.

    I think a lot of the argument for Occam's Razor arises in harder sciences like physics. Simpler equations are often preferred. Biology is messy. We are talking of systems of things interacting. Reductionism and critical rationalism, and heuristics like Occam's Razor, start to meet their limits here, and really fail when it comes to psychology or psychiatry.
     
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  2. MeSci

    MeSci ME/CFS since 1995; activity level 6?

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    and we have higher levels of IL-10 than controls according to this paper.
     
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  3. wastwater

    wastwater Senior Member

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    I'm likely missing a gene IRF4 interferon regulatory factor 4 that gives rise to problems with EBV
    Hope they continued this work
    I don't know if this would make me a candidate for rituximab and what that would do
    If b cells are undifferentiated does that make them anaplastic
     
    Last edited: May 23, 2017
  4. katcoff

    katcoff

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    I've had CFS/ME for many years. Back when, I tested negative for mono, which I assume looked for EBV (or whatever). So yes,it makes me wonder if the real problem is lack of adequate immune reaction to the virus, a lack I still have.
     
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