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Defensins associated with slower HIV progression

Discussion in 'Other Health News and Research' started by raul, Feb 25, 2010.

  1. raul

    raul

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    http://www.plosone.org/article/info:doi/10.1371/journal.pone.0009436

    [From the abstract]

    Conclusions/Significance

    High production of α-defensins1-3 by immature DCs appears as a host protective factor against progression of HIV-1infection, suggesting potential diagnostic, therapeutic and preventive implications. This protective effect may arise from the activity of α-defensins1-3 to damage the virions prior and/or after their internalization by immature DC, and hence favoring a more efficient viral processing and presentation to HIV-specific CD4+ T cells, without or with a minor rate of transmission of infectious HIV-1 virions

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