Review: 'Through the Shadowlands’ describes Julie Rehmeyer's ME/CFS Odyssey
I should note at the outset that this review is based on an audio version of the galleys and the epilogue from the finished work. Julie Rehmeyer sent me the final version as a PDF, but for some reason my text to voice software (Kurzweil) had issues with it. I understand that it is...
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Defective T-cell control of EBV infection in multiple sclerosis

Discussion in 'Other Health News and Research' started by pattismith, Jan 17, 2018.

  1. pattismith

    pattismith Senior Member

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    Defective T-cell control of Epstein–Barr virus infection in multiple sclerosis

    Published online 20 January 2017

    Michael P Pender, Peter A Csurhes, Jacqueline M Burrows and Scott R Burrows

    Abstract

    Mounting evidence indicates that infection with Epstein–Barr virus (EBV) has a major role in the pathogenesis of multiple sclerosis (MS).

    Defective elimination of EBV-infected B cells by CD8+ T cells might cause MS by allowing EBV-infected autoreactive B cells to accumulate in the brain.

    Here we undertake a comprehensive analysis of the T-cell response to EBV in MS, using flow cytometry and intracellular IFN-γ staining to measure T-cell responses to EBV-infected autologous lymphoblastoid cell lines and pools of human leukocyte antigen (HLA)-class-I-restricted peptides from EBV lytic or latent proteins and cytomegalovirus (CMV), in 95 patients and 56 EBV-seropositive healthy subjects. In 20 HLA-A2+ healthy subjects and 20 HLA-A2+ patients we also analysed CD8+ T cells specific for individual peptides, measured by binding to HLA-peptide complexes and production of IFN-γ, TNF-α and IL-2.

    We found a decreased CD8+ T-cell response to EBV lytic, but not CMV lytic, antigens at the onset of MS and at all subsequent disease stages.

    CD8+ T cells directed against EBV latent antigens were increased but had reduced cytokine polyfunctionality indicating T-cell exhaustion.

    During attacks the EBV-specific CD4+ and CD8+ T-cell populations expanded, with increased functionality of latent-specific CD8+ T cells.

    With increasing disease duration, EBV-specific CD4+ and CD8+ T cells progressively declined, consistent with T-cell exhaustion.

    The anti-EBNA1 IgG titre correlated inversely with the EBV-specific CD8+ T-cell frequency.

    We postulate that defective CD8+ T-cell control of EBV reactivation leads to an expanded population of latently infected cells, including autoreactive B cells.
     
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  2. Tammy

    Tammy Senior Member

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    New Mexico
    I agree................and that's why there are so MANY overlapping symptoms of CFS and MS. With some cases of aggressive MS, I believe it's because of a more aggressive strain of EBV.
     
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  3. raghav

    raghav Senior Member

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    I suffer from hippocampal sclerosis with atrophy. Is it a milder version of MS ? My fatigue started only after this.
     
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  4. ljimbo423

    ljimbo423 Senior Member

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    I think this study shows immune system dysfunction causing high EBV titers, not increased viral load. The PCR testing for viral load is not "statistically significant".

    Jim
     
    Last edited: Jan 18, 2018
    andyguitar likes this.

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