It's clear to me when using binders such as Activated Charcoal and Bentonite Clay, my need for B12 eventually decreases when taking a combination of binders. I'm not sure if these are really binding toxins well, or just impairing bile flow. It seems as if when my gallbladder becomes less sluggish and clears itself out, symptoms return with a feeling of toxicity. For me, the symptoms become quite severe both physically, neurologically, but megadoses of B12 + other vitamins helps a ton. I've been having pain and distension of the gallbladder lately. Again, when this sludge or whatever it is finally decides to dump, the toxicity feeling can hit hard. At this point, these toxins or whatever they are feel as if they recirculate causing a lot of symptoms until the gallbladder fills back up again becomes sluggish once again. I think if one didn't have a sluggish gallbladder, they would probably just feel more or less constantly ill and not be able to feel this cycle. While I benefit greatly from methylation (specifically Freddd's high dose protocol), I do not feel that this will solve the problem of what I think are recirculating neurotoxins. I got sick in 2008 while living in Lake Tahoe. I had a bacterial infection (not a virus!) originally diagnosed and treated as Lyme disease. I don't live in a moldy house, but I may have when living in Tahoe. I didn't know how sensitive I was to mold until staying in very bad and musty buildings on the East Coast. I do meet all the criteria for ME/CFS (including biomarkers) and have the typical associated syndromes as well. If others have these same type of neurotoxins, I do not think methylation/glutathione will ever address the issue. I'm not claiming I have a solution - but this is my opinion. I will be trying Cholestyramine soon.