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Decreased Brain Levels of Vitamin B12 in Aging, Autism and Schizophrenia

hixxy

hixxy

Senior Member
Messages
1,229
Location
Australia
Interesting study, although not really about ME/CFS, but seems relevant:

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0146797

I haven't read the whole thing but I found this excerpt interesting in relation to the active b12 protocol:

The supplemented form of vitamin B12 (commonly CNCbl) must be converted to the active MeCbl and AdoCbl species, which requires adequate levels of GSH and NADPH, and a functional vitamin B12 deficiency state may result when levels of these reducing factors are low, as in oxidative stress. Thus supplementation with supraphysiological levels of the active Cbl species (i.e. MeCbl and AdoCbl) may be required to address an oxidative stress-related functional deficiency.
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