This is one case study of CFS and NOT deconditioning. I am your typical ME patient: PEM, OI, Lessions in brain, Low T cells, Low NK cell, High B cell, Viral Re activations........ (all verified by tests). I see one of the Best CFS specialists. (I have tested and proven not to be depressed). I just wanted to tell you that I am a very particular case, I am in the high functional spectrum ON AND OFF, I am more like a remitting, relapsing type. So I do not buy the deconditioning theory because I am the prime example that I can go from one day to the other to be in bed and being unable to brush my teeth, to a few days later to live a normal life. I work full time and have a house and a family to tend to. I get remissions from colds and My period (second day and on) where I am a normal person with no limitations. When I get a cold, I can run for a bit if I want, which is my major relapse trigger for me. So how do you explain that I can be in the worse of crashes, I get a cold and I can go running with no pay back. My colds only last a day or 2 tops (and I rarely gets them) so the relief is no long lived. In this period of lucidness I can tell the big difference and what ME really feels like. I have that blessing where most don't ever feel normal. My point is the following. If you have ME even when you are on good periods, and I can exercise and lead a mostly normal life. I STILL have ME, I still suffer from symptoms as much as I did when I was bed ridden. I am more active than most people around me despite of being sick. I see my co-workers and their sedentary life, and they do not have symptoms as I do. The being unable to brush my teeth, take a shower or even go up the stairs, come and go like everything else for me. So I am all open to donate blood, being study or whatever. But stop saying we get this bad because is deconditioning!!!! there is something else going on at the core of the disease that brings us down to our knees. FIND IT.