I came down with something very similar to CFS around December of 2013. In November I had started on a very low carb diet, and that initiated a large water weight loss that I probably could not afford. I started at a lean 170 and went to 159. As I lost the weight extreme fatigue set into my muscles, and no amount of food or water appeared to correct whatever it was I had broken with the diet. I went from working 14 hours a day to three hours, and even during those three hours I had no real muscle energy. I had a strong mental fog as well. I want to describe briefly how I proceeded, and what I have done to treat this. The first shock for me was that no one in the medical system sees this as a real disease, and once each specialist rules out one of the major diseases that he treats, they simply stop working on your case. I think this is why so many CFS people end up having to become their own general practitioner and do so much research on their own. At its worst, what would happen is that I would do some high intensity exercise like sprinting, and I would then become desperate for water, and I would spend an entire night exhaling rapidly and drinking large amounts of water. Unfortunately, my body would excrete the water rapidly and I would never get rehydrated. It's really strange to me that I would describe these extreme symptoms to multiple doctors, and none of them registered that this was something worth investigating. It was like I was describing taking out the garbage to them, and what did they have to do with that? To me the patient, these experiences felt like I was in the end stage of a terminal disease. What could be worse than going out for a normal exercise session and ending up fatigued, dehydrated, and your body signaling the abnormality by changing your breathing pattern to rapid deep respirations? After months of dead ends, my big breakthrough came when I realized that salt water improved my condition. It did not remove the muscle fatigue, but it certainly improved it for about two hours after each salt infusion. That made me believe I had an electrolyte issue, but the electrolyte tests all showed normal ranges. The exception to that was a low sodium result once, but I caused that result by drinking one liter of water every hour during one of these episodes of dehydration. It turns out that low sodium can be caused by drinking too much water. More researching and then it all came together. What I realized is that my muscles are not releasing lactic acid. Even minor lifting of heavy objects is enough to produce enough lactic acid to fatigue the muscle. And since the body is not clearing that acid, the fatigue it causes extends out to days and weeks, as additional exercise keeps adding onto the lactic overload. Then I realized that my abnormal breathing was in fact the body compensating for metabolic acidosis. The lactic / metabolic overload of acid in my muscle was causing my body to compensate to lower my pH by forcing my respiration to rapidly exhale CO2. The body is breathing out extra acid in order to keep body pH normalized. This is when all of the pieces came into place for me. In reading about how to clear lactic acid, I read that many people have luck using sodium bicarbonate. There are reports of vinegar and vitamin c/acetic acid also supporting one of the metabolic cycles that clears lactic acid. A few weeks ago I replaced my salt infusions with sodium bicarbonate. The response was immediate, and rapid. All of the muscle fatigue started to lift. Within two days of taking 1/4 teaspoon of sodium bicarbonate on an empty stomach eight times a day, the muscles felt back to about 60% of normal. And every day since then it gets better. Unfortunately, this amount of sodium bicarbonate gives you a lot of sodium. So I am looking in the near future to transition to potassium bicarbonate. There is good research showing that potassium in therapeutic doses will spare the body from using calcium as a pH buffer, and bone loss markers improve. The RDA for potassium is around five grams, and most people in US get less than three grams from diet. My goal for now is to start supplementing somewhere around four grams of potassium and maybe 1/2 gram of sodium, to keep the potassium to sodium ratio high, and to minimize any sodium intake. I am not advocating that anyone do any of the above steps. A person with normal kidney function should be able to easily handle four grams of potassium. Someone with impaired kidney function, or taking certain drugs, might not deal with it well. At this point it is too early to say I am cured. I feel like I am treating symptoms not causes. But I am starting to gain back the lost weight and starting to recover my muscle energy. The brain fog is still there but is slowly improving. If I can hold the body weight and start exercising, I am hoping I will continue to make progress. I am curious if any of you have tried to treat CFS as a kind of chronic metabolic acidosis. Have you had luck with any specific therapy that addresses that issue?