My daughter is 14 and diagnosed with POTS at ANS disorders clinic. She has a persistant low BP and tachy when standing. Her BP drops when standing initially. She has been prescribed a low dose beta blocker: Bystolic and Zoloft (to help raise BP and Im assuming from blood vessel constriction?) She is of course to increase fluid and salt intake, etc. I am concerned to give her the SSRI and am thinking about her Yasko Nutrigenomic Methylation panel results: She is homozygous for MAO and heterozygous for COMTs. I know there is a relationship here with both of these snps and seratonin. I think Yasko recommends low dosing 5-htp through out the day to keep serotonin more stable because as I understand, it can swing which can cause mood swings. I need to get back into the Yasko info. Its been a while. I am also concerned because she has an ACE deletion and not sure how supplementing with high dose salt 3000grams a day effects that. Thoughts and experiences would be appreciated, even if it is to tell me its good to take the SSRI! She does not have CFS and her main symptoms are the POTS (which is presenting mostly as tachy, grey outs and being very anxious). I have developed the CFS and hope to keep her out of my spectrum. I am crashing constantly esp with detox (obviously its own thread). Thanks so much!