hello there, i would like to know, who got immediate onset of dark circles under eyes when got M.E.? If so, what was the cause of your M.E.? Virus? Hormonal? In my case, 2-3 days after rapid onset of M.E. i developed dark circles under my eyes, but only in the corner between eye and nose. I tried everything to let them disappear.. all Vitamins are in full range upper limit.. All Hormones are good. A long time I thought, my ME problem is due thyroid-conditions.. but now i think, this was the whole wrong way.. because i had inflammed tonsils, swollen lymphnodes under arms, fatigue and sweating when i got sick.. with immediate onset of dark circles. I started 2 days ago to treat EBV and CMV with valcyte.