The Real ME: A Stock Photography Resource for the Media
We’ve all seen them in the news stories about ME/CFS: the guy in a suit at the office, yawning; the beautiful woman sitting at her desk with her immaculate make-up and elegantly coiffed hair, hand to her head and looking slightly pained.
Discuss the article on the Forums.

Dane Cook needs 3 more patients for his PEM study--women in Madison, WI

Discussion in 'Active Clinical Studies' started by waiting, Sep 18, 2014.

  1. waiting

    waiting Senior Member

    Messages:
    449
    Likes:
    866
    During the CAA webinar(just finished -- was recorded and will be posted to SolveCFS), the presenter, Dane Cook, said he needs 3 more volunteer patients to complete his clinical study.

    - An Investigation of PEM in CFS
    - University of Wisconsin
    - requires 3 visits to campus
    - blood tests, sub maximal exercise test and MRI
    - $225 for time & effort
    - call tel: 608-262-2457
     
    Last edited: Sep 18, 2014
    Dolphin, Little Bluestem, Sea and 2 others like this.
  2. Keela Too

    Keela Too Sally Burch

    Messages:
    847
    Likes:
    3,715
    N.Ireland
    I missed the beginning of this presentation, but thought it very interesting.
     
  3. waiting

    waiting Senior Member

    Messages:
    449
    Likes:
    866
    Yes, I may have missed this part, but I am wondering in which ways it adds to the previous Lights' gene expression studies. Is it considered a replication study? I'm guessing not, since it includes Dr Alan Light, who authored the original gene expression study.
     
  4. Dolphin

    Dolphin Senior Member

    Messages:
    10,574
    Likes:
    27,643
    Video is up at:

    Healthies or people with CFS or both? I don't have time/energy to watch at the moment.
     
    Keela Too likes this.
  5. waiting

    waiting Senior Member

    Messages:
    449
    Likes:
    866
    I can't recall! :thumbdown: I'm assuming PWC ... or you could call the number and ask them the question if you think you'd like to volunteer.
     
  6. Dolphin

    Dolphin Senior Member

    Messages:
    10,574
    Likes:
    27,643
    Can't volunteer - wrong side of the Atlantic - but would like to get the message out.
     
    ukxmrv likes this.
  7. Little Bluestem

    Little Bluestem Senescent on the Illinois Prairie ❀❤✿Ƹ̵̡Ӝ̵̨̄Ʒ✿❤❀

    Messages:
    4,603
    Likes:
    5,182
    Midwest, USA
    I’m on the right side of the Atlantic, but too far away to get to Madison 3 times for $225.

    Does anyone know Mr. Cook’s view of CFS? I did a little search on him and found more references to psychology that I was comfortable with.

     
    ukxmrv likes this.
  8. ukxmrv

    ukxmrv Senior Member

    Messages:
    4,242
    Likes:
    4,132
    London
    I'd value others opinions on this. Ran through the video yesterday but having trouble taking it all in and ran through it again today. Had to replay a few area that didn't sink it.

    The study appears to be tying in the work of the Lights on gene expression after exercise. However it is going to have a very specific slant to it. They will be taking a number of different tests from patients (think lactic acid in blood and lots more) but the main thrust of it is going to be how patients perform a series of mental cognitive tests and how that ties in with the other results. More importantly it is going to concentrate on brain scans of the patients.


    I'm going to have to find the paper from Jacob Meyer (sp?) in 2013 and see where that went as it was mentioned in this study.
     
    Last edited: Sep 25, 2014
  9. MeSci

    MeSci ME/CFS since 1995; activity level 6?

    Messages:
    7,902
    Likes:
    12,507
    Cornwall, UK
    If he wants more patients I would guess that he would mean ME/CFS patients, as otherwise the illness would be specified, wouldn't it? And participants in research are called subjects rather than patients.
     
  10. Dolphin

    Dolphin Senior Member

    Messages:
    10,574
    Likes:
    27,643
    Yes, but the initial poster may have interpreted what he said rather than remembering it exactly (e.g. maybe "subjects" was used instead). And the "volunteer" part would be more likely to be used for healthies I would think. Also, it is often harder to get the healthy volunteers. So I don't think we can be sure.
     
    MeSci likes this.
  11. ukxmrv

    ukxmrv Senior Member

    Messages:
    4,242
    Likes:
    4,132
    London
    Found it. The first 19 minutes of the Webinar were spent describing this paper (from the same stable and also commissioned by SolveME/CFS initiatve (used to be the CFIDS Association)

    Abstract
    Background: A primary complaint of chronic fatigue syndrome (CFS) patients is post-exertion malaise, which is a worsening of symptoms following activities such as exercise. Purpose: To examine the link between gene expression for metabolite, adrenergic, immune, and glucocorticoid receptors on leukocytes and symptoms (pain, fatigue, and mood) following a maximal exercise test. Methods: Thirteen CFS patients and 11 healthy participants matched on age and fitness underwent blood draws and completed questionnaires immediately before, and 15 minutes, 48 hours, and 72 hours following, maximal exercise. Symptom and genetic measures collected before and after exercise were compared using a doubly multivariate repeated-measures analysis of variance. Results: This comparison of CFS and healthy participants resulted in a significant multivariate main effect for Group (p < 0.05). Univariate analyses indicated group differences for adrenergic α-2A and glucocorticoid (NR3C1) receptor messenger ribonucleic acid and symptoms of fatigue and confusion. Changes in gene expression were significantly correlated with symptoms. Conclusions: Results suggest that increased glucocorticoid sensitivity may contribute to the symptoms of post-exertion malaise in CFS. As NR3C1 interacts with other transcription factors, investigating the resulting cascades may lead to greater understanding of the biological mechanism of post-exertion malaise. This finding, if confirmed, could lead to novel approaches to prevent symptom exacerbation in CFS.

    http://www.tandfonline.com/doi/abs/10.1080/21641846.2013.838444#.VCQY6vldUlI

    There's a previous PR discussion of the paper here

    http://forums.phoenixrising.me/inde...per-alpa-2a-glutocorticoid-implication.25711/
     
    Last edited: Sep 25, 2014
    MeSci likes this.
  12. ukxmrv

    ukxmrv Senior Member

    Messages:
    4,242
    Likes:
    4,132
    London
    My question is - after the Lights research was published on gene expression changes after exercise in CFS what did we expect to happen next?

    This for the old CFIDS Association (now called Solve ME initiative) is the next "next".

    The first "next" was to commission research on gene expression of some specific receptors and some PEM symptoms in patients. That research returned a relationship between some adrenergic and glucocorticoid receptors and the symptoms of fatigue and confusion after exercise they said.

    Now they have commissioned the same team to look at the MRI brain activity of patients before and after exercise when they perform fatiguing cognitive tests. It's for this research volunteers are needed. They will also be doing gene expression and metabolics but I get the impression it is brain activity that is their focus.

    Some comments on the Webinar (and I'll add to this)

    The first part of the talk by Dane Cook explains the paper initial above (Meyer et al). That's about 19 minutes long. The "take home"message from this is that they regard the differences in gene expression of the glucocorticoid receptor to be the reason for the fatigue patients feel after exercise.

    There is no mention of any immunological findings from the Lights or much about immunology.

    They talk about interactions between different physiological systems but the focus appears to be on the brain. I think it is important that this is their focus and I would appreciate other's opinions on if I have got this right.

    The new research project is going to be on PEM and brain function during cognitive tasks using an MRI machine. It goes something like this

    They will take patients symptoms, take blood samples for gene expression, then scan their brains using MRI whilst they perform "not fatiguing" and "non fatiguing" cognitive tests like mentally adding numbers, number recognition, measure physical activity for 1 week, take blood, symptoms, exercise to 70%, take metabolics (Oxygen/lactate and others).

    24 hours later = more tests

    Dane talks about some data from patients already(no idea where this comes from?) This time it sounds as if they will take 10 different symptoms (not the 3 or 4 studied previously) - chills, muscle pain, concentration, fever, joint pain, headache, sore throat, fatigue, memory, lymph.

    I'm still working and trying to understand the Webinar so will be adding to this and correcting. Please send me a PM if I have anything horribly wrong.


    TBC
     
    Last edited: Sep 26, 2014
    Valentijn and MeSci like this.
  13. Little Bluestem

    Little Bluestem Senescent on the Illinois Prairie ❀❤✿Ƹ̵̡Ӝ̵̨̄Ʒ✿❤❀

    Messages:
    4,603
    Likes:
    5,182
    Midwest, USA
    I found the notes I took on Dane Cook.

    His research interests stated on his U of WI website:


    He works in the Exercise Psychology Lab and Human Behavior and Motor Control Lab.

    The term psychophysiological showed up several times.
     
    Valentijn and MeSci like this.
  14. Dolphin

    Dolphin Senior Member

    Messages:
    10,574
    Likes:
    27,643
    Here's an image people can use to help attract volunteers:
    10514696_10152312860462108_1222033888936898287_n.jpg
     
    Valentijn likes this.

See more popular forum discussions.

Share This Page