Snow Leopard
Hibernating
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- South Australia
I noticed that Griffith University (Australia) had the following as a research project:
See:
http://en.wikipedia.org/wiki/DAMPs
http://en.wikipedia.org/wiki/Pathogen-associated_molecular_pattern
Along with this interesting hypotheses such as:
"Dangers Within: DAMP Responses to Damage and Cell Death in Kidney Disease" (open access)
http://jasn.asnjournals.org/content/22/3/416.full
DAMPs have been suggested as possible risk factors leading to (regulatory) loss of control of antibody producing cells. There is also the possiblity of DAMPs themselves causing antibody independent feedback loops resulting in immune system dysregulation.
I am a little skepetical, at least with regards to the role in CFS, but it seems like an interesting avenue.
I am wondering what @Jonathan Edwards and others think about this?
Prof. Sonya Marshall-Gradisnik
Phone: *removed*
Email: *removed*
Chronic Fatigue Syndrome (CFS) is a heterogeneous and multifactorial disorder that affects many individuals worldwide. There is currently no definitive diagnosis for CFS and an exact mechanism to explain the manifestation of this disorder remains to be determined. However, CFS is known to be associated with alterations in immune function including NK activity, neutrophil phagocytosis and cytokine distribution. The National Centre for Neuroimmunology and Emerging Diseases (NCNED) is a leading research centre for CFS/ME research. The primary focus of this research centre is to determine markers for CFS/ME diagnosis by examining molecular and cellular parameters. It is well known that the immune system in CFS/ME is severely compromised
Project 1. An Investigation of the Inflammasome in Chronic Fatigue Syndrome
Infection and insults to tissues induces inflammation. The immune system has receptors that recognise pathogen associated molecular patterns (PAMPS) released by pathogens and damaged associated molecular patterns (DAMPS) released by the host in response to the pathogen invasion. These receptors form complexes that induce caspases and pro-inflammatory cytokines. The recognition of reduced cytotoxic activity, impaired neutrophil function and altered production of cytokines in CFS/ME are suggestive of persistent pathogen infiltration possibly causing increases in inflammation. This project examines these PAMPS and DAMPS and their receptors in CFS/ME to determine their role in the impaired immune profiles observed in these patients
See:
http://en.wikipedia.org/wiki/DAMPs
http://en.wikipedia.org/wiki/Pathogen-associated_molecular_pattern
Along with this interesting hypotheses such as:
"Dangers Within: DAMP Responses to Damage and Cell Death in Kidney Disease" (open access)
http://jasn.asnjournals.org/content/22/3/416.full
DAMPs have been suggested as possible risk factors leading to (regulatory) loss of control of antibody producing cells. There is also the possiblity of DAMPs themselves causing antibody independent feedback loops resulting in immune system dysregulation.
I am a little skepetical, at least with regards to the role in CFS, but it seems like an interesting avenue.
I am wondering what @Jonathan Edwards and others think about this?
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