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Damage-associated molecular patterns stimulate interleukin-33 expression in nasal polyp epithelial c

Discussion in 'Fungal Infection (Yeast, Candida)' started by osisposis, Oct 15, 2014.

  1. osisposis

    osisposis Senior Member

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    Valentijn likes this.
  2. ukxmrv

    ukxmrv Senior Member

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    London
    Thank you for posting that

    "The present study demonstrates that SNECs derived from recalcitrant CRSwNP patients express the cytokine IL-33 in response to damage-associated molecular patterns in vitro. Moreover, whereas the expression of IL-33 is largely confined to the nuclei of basal epithelial cells in control subject ethmoid mucosa, tissue samples from recalcitrant CRSwNP frequently display IL-33 protein expression in the nuclei of more apically-located cells with extension into the cytoplasm. Because IL-33 has the capacity to activate Th2 cytokine-producing innate lymphoid cells residing in the sinus mucosa, dysregulation of this pathway may play a part in perpetuating eosinophilic inflammation in CRSwNP patients who are recalcitrant to medical and surgical therapy."
     
    Valentijn and osisposis like this.
  3. South

    South Senior Member

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    Can someone smarter than me translate that if possible, are there steps a person with candida and sinus problems might do with the study information? It is so far over my head. Is it more of a study proving some kind of background info, not really yet useable for people (and hopefully in the future more study might yield some steps real people can take)?
     
  4. osisposis

    osisposis Senior Member

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    Biomed Res Int. 2014;2014:587376. doi: 10.1155/2014/587376. Epub 2014 Jun 16.
    Role of IL-33 and its receptor in T cell-mediated autoimmune diseases.
    Zhao Q, Chen G.
    Author information
    Abstract

    http://www.ncbi.nlm.nih.gov/pubmed/25032216


    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084552/


    Curr Allergy Asthma Rep. 2013 Apr;13(2):196-202. doi: 10.1007/s11882-013-0338-z.
    The role of interleukin-33 in rhinitis.
    Rogala B1, Glück J.
    Author information
    Abstract

    http://www.ncbi.nlm.nih.gov/pubmed/23381303


    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585988/


    Allergol Int. 2013 Mar;62(1):13-20. doi: 10.2332/allergolint.13-RAI-0538.
    Role of interleukin-33 in innate-type immune cells in allergy.
    Nakae S1, Morita H, Ohno T, Arae K, Matsumoto K, Saito H.
    Author information
    Abstract

    http://www.ncbi.nlm.nih.gov/pubmed/23439054
    Am J Rhinol Allergy. 2010 Mar-Apr;24(2):105-9. doi: 10.2500/ajra.2010.24.3446.
    Treatment-recalcitrant chronic rhinosinusitis with polyps is associated with altered epithelial cell expression of interleukin-33.
    Reh DD1, Wang Y, Ramanathan M Jr, Lane AP.
    Author information
    Abstract
    BACKGROUND:

    Abnormalities in host mucosal immunity exist in chronic rhinosinusitis with nasal polyps (CRSwNPs), but it is unclear whether this is a cause or an effect of the eosinophilic inflammation and frequent microbial colonization that characterizes the disease. Sinonasal epithelial cells (SNECs) are critical participants in healthy antimicrobial innate immune defense. They also can promote Th2 inflammation with various mediators, including interleukin (IL)-33, which induces T helper cells to produce Th2 cytokines.
    METHODS:

    CRSwNP SNECs were obtained during sinus surgery and stored. Patients were subsequently classified as either treatment responsive or treatment recalcitrant, based on long-term outcomes of medical and surgical therapy. Epithelial cells from these patients were grown in air-liquid interface (ALI) culture and treated with IL-13, as well as the bacteria-associated molecule, CpG. Expression of IL-33 mRNA was determined by real-time polymerase chain reaction.
    RESULTS:

    http://www.ncbi.nlm.nih.gov/pubmed/20338108



    ScientificWorldJournal. 2014;2014:340690. Epub 2014 Jul 21.
    The Role of IL-33 in Host Response to Candida albicans.
    Rodríguez-Cerdeira C1, Lopez-Bárcenas A2, Sánchez-Blanco B3, Arenas R4.
    Author information
    Abstract

    http://www.ncbi.nlm.nih.gov/pubmed/25136658

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130336/
     

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