New era for ME/CFS research as top cytokine study attracts media headlines
The immune systems of patients who have recently developed ME/CFS look markedly different from those who have been ill for much longer, according to a major new study from Drs. Ian Lipkin and Mady Hornig at Columbia University. This shift in immune function hadn’t been seen before.
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Daily Mail: Driven insane by your own immune system...

Discussion in 'Other Health News and Research' started by Firestormm, May 2, 2013.

  1. Firestormm

    Firestormm Guest

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    For rest of the article see here.​
     
    merylg, Enid, PhoenixDown and 2 others like this.
  2. Firestormm

    Firestormm Guest

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    Maybe if I'd added 'Rituximab' to the title of this thread it might gain more attention. Interesting article all the same. And of interest in our world I would think.
     
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  3. adreno

    adreno on the beach

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    Seems that the strategy of blocking NMDA receptors (in order to reduce excitotoxicity) that many seem to advocate might not always be a good idea. I certainly get extremely brain-fogged from NMDA antagonists. Stimulating the NMDA might actually be a more viable option in these cases.
     
  4. Bob

    Bob

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    Interesting article, thanks Firestormm.

    There seem to be a number of parallels with ME/CFS. (e.g. Rituximab, Herpes virus, and auto-immunity.)
     
  5. Firestormm

    Firestormm Guest

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    Not that I read the Daily Wail you understand, Bob :) Charles flagged it on MEA Facebook earlier. Makes one think and I do like articles like that. It's all biology at the end of the day - however it's categorised.
     
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  6. Ian

    Ian Senior Member

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    She probably has an amalgam filling
     
  7. Marco

    Marco Old blackguard

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    It does depend on which antibodies you have :

    Anti-NMDA receptor encephalitis and late onset autism are recently recognised and related autoimmune disorders involving antibodies to NMDA(glutamatergic) receptors with prodromal symptoms reminiscent of a viral infection and that result in a wide range of movement and neuropsychiatric symptoms and neuroinflammation. (Dalmau et al, 2011).

    Autoimmune encephalitis (where symptoms include psychiatric features, confusion, memory loss and seizures followed by a movement disorder, loss of consciousness and autonomic fluctuations) and related disorders have also been associated with anti GABA-B receptor antibodies and/or glutamic acid decarboxylase (GAD – the enzyme responsible for converting glutamic acid to GABA) antibodies (Boronat et al, 2011). One recent hypothesis (Fitzgerald, Carter, 2011) proposes decreased GAD expression or activity as playing a key role in fibromyalgia.

    Rituximab has also been used to treat anti-NMDA receptor encephalitis (Ikeguchi et al, 2012) supporting a close link between autoimmunity, glutamate/GABA and encephalitis.
     
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  8. AbbyDear

    AbbyDear

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    interesting. i have been trying to share this idea for some time - because of how i feel, and react (mcs). docs have no clue. here another link to consider (an old article - i not a fan of antidepressants...so read with a bit of caution):
    http://www.cytokines-and-depression.com/chapter1.html
    and books:
    http://www.amazon.com/Cytokines-Stress-Immunity-Second-Edition/dp/0849320747/ref=sr_1_1?ie=UTF8&qid=1367569510&sr=8-1&keywords=cytokines stress
    ...
    http://www.amazon.com/Chronic-Fatig...=UTF8&qid=1367569560&sr=1-10&keywords=patarca
     

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