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DAAO and GlyT1 inhibitors in treatment of Alzheimers, OCD, depression, schizophrenia, and more

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by pgoody, Jul 26, 2013.

  1. pgoody


    Here is an abstract that discusses the current thoughts behind this kind of treatment:

    Currently the top two GlyT1 inhibitors available are sarcosine (an endogenous inhibitor) and Bitopertin (which will be marketed come 2015?).

    D-amino acid oxidase (DAAO) inhibitors inhibit the breakdown of d-serine (and other D-amino acids). D-serine is an endogenous co-agonist of the NMDA glycine/d-serine site.

    A few more links: more in depth explanation for OCD for depression sodium benzoate, a potential DAAO inhibiting agent for Alzheimers

    There are likely other DAAO agents being tested, as I have read some material about this dating back at least 5 years. Sodium benzoate was something I just spotted on this particular site.

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