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D-ribose - can it make you feel bad?

Discussion in 'General Treatment' started by Sasha, May 13, 2013.

  1. Allyson

    Allyson Senior Member

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    yes Sasha,

    I noted no ill effects but i was SO gald to get relief form the constant aches

    - it is cheaper at iherb - 27 dollars still a lot though

    some people - i have read - it gives more energy though i never heard anyone say that
    it did not do that for me alas.

    it is yummy though so i just use it like sugar - a change from all those yuk meds!
    Sasha likes this.
  2. soxfan

    soxfan Senior Member

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    I just started D-Ribose a week ago. I am currently using only one scoop in the morning and then will go up to another scoop at lunch. I don't feel anything at all...good or bad. Maybe once I get up to the 2nd dose I will. I did try it years ago and didn't notice anything at 3X a day but decided to give it another try....
    Mine is a powder that I put into liquid and drink....
  3. GhostGum

    GhostGum Senior Member

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    What brand are you using? A little while ago I noticed the smell and taste of the Now d-ribose had changed, it went from a nice brown sugar like smell and taste to an almost rubbing alcohol/metho type smell and taste which was terrible; turned out their manufacturer changed their recipe, probably to save a few bucks. I ended up changing brands but can not find that lovely old sweet sugary stuff.

    Sorry it did not work out too well for you Sasha. I have also found it quite useful for muscle soreness.
  4. Lotus97

    Lotus97 Senior Member

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    I think all the brands have that smell because they all use Bioenergy Ribose® I tried NutraBio's ribose because I thought it would be different, but it also has the same smell. I didn't think they used Bioenergy though (?)
  5. Sasha

    Sasha Fine, thank you

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    Mine is by Deluxe Nutrition and it smells a bit like caramel in the tub - I was drinking it mixed in with other stuff so I can't attest to the flavour.
  6. Marlène

    Marlène Senior Member

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    I started to use it about 10 days ago, 3 teaspoons a day. At first I did not notice much, so I stopped after 5-6 days.

    Then I changed tactics. I now take a teaspoon AFTER exercise and my muscles recover much quicker!
    rosie26 and Sasha like this.
  7. Sasha

    Sasha Fine, thank you

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    V. happy to say I'm feeling much better, having not had any for only 24 hours - not back to baseline but a long way towards it.

    Phew! Thanks for the supportive messages in my hour of crisis - it really did help cheer me up. I felt like death. :aghhh:
  8. perchance dreamer

    perchance dreamer Senior Member

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    For me, the brand of ribose makes a big difference. I got only a weak energy effect from a full dose of Carlsons and Corvalen when I took them a long time ago. I seem to remember that Carlsons is 3 grams, and Corvalen is 5 grams. It really wasn't enough to make it worth taking. I didn't have any side effects.

    After that I got Jarrow powdered ribose. A full dose is 1/2 tsp, 2 grams. The one time I took the full dose (in the morning) I had great energy, but sleep that night was hopeless. After experimenting, I found I can only take 1/64 tsp. of Jarrow ribose without it affecting my sleep.

    My nutritionist told me his wife had the same reaction to Jarrow ribose. However, if you look at Iherb and Amazon reviews, it seems that loads of people do great with Jarrow.
  9. Lotus97

    Lotus97 Senior Member

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    Jarrow uses Bioenergy Ribose like most brands, but I don't see anything about Carlson or Corvalen using Bioenergy. On Corvalen it says "Bioenergy Life Science", but that might be a coincidence because I don't see the trademark Bioenergy Ribose® on Corvalen. Most other brands use Bioenergy so I can't imagine them being different than Jarrow's. It's just that the other two you tried happened to be ones made by other suppliers.

    I've also heard of people having hypersensitivity to carnitine, adenosylcobalamin, coenzyme q10/ubiquinol, biotin, and maybe a few others. So after hearing what happened to you and Dreambirdie with D-ribose it seems that certain ATP/Krebs supplements might have that effect on people. It's possible you need to do other things first to get your Krebs cycle functioning properly before you can tolerate some of the other supplements. I don't know much about this, but based on some of the things I've heard from others about this it might be true.
    Sasha likes this.
  10. perchance dreamer

    perchance dreamer Senior Member

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    I think you're probably right, Lotus. Both carnitine (other than GPLC) and biotin cause me sleep problems. I'll look into the Krebs cycle thing. Thanks.
  11. Lotus97

    Lotus97 Senior Member

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    A good place to start would be the B vitamins. Those along with the other vitamins and minerals are basic building blocks for so many functions in the body. I had problems with biotin too and this is what Jeffrez and dbkita told me:
  12. Lotus97

    Lotus97 Senior Member

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    According to this study, getting Krebs and ATP should actually help sleep (rather than interfere with sleep)
    http://www.sciencedaily.com/releases/2010/09/100914100302.htm#
  13. rlc

    rlc Senior Member

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    Hi Sasha, D ribose is naturally made by the body, but unfortunately this is a slow process. When people have a chronic disease, this wears out the Mitochondria, which leads to a need for more D ribose then the body can produce, which is why so many people feel better when they take it.

    However D-Ribose lowers blood sugar see http://www.bioenergy.com/pdf/mf/sl/Ribose%20&%20Blood%20Sugar/Ribose_Blood%20Sugar_Science%20070303.pdf

    This slight lower of blood sugar is not enough to cause major side effects in anyone, unless they already have a condition that lowers blood sugar (hypoglycemia). Hypoglycemia is caused by many conditions such as diabetes, pre diabetes, pancreatic disease, liver and renal diseases and other endocrine disorders and medications etc. A full list of its causes are found here http://en.diagnosispro.com/differential_diagnosis-for/vegetative-autonomic-endocrine-disorders-hypoglycemia-causes/10859-154-220.html there are 222 possible causes, if you have any failed test results though, this diagnostic software program will be able to reduce the number of possibilities very quickly.

    As far as medical science knows at the moment, someone already having a condition that causes hypoglycemia is the only cause of serious side effects with D ribose.

    Candida will of course get worse if someone consumes large amounts of sugar, however if your health has declined so much, in such a short period of time, with what is a relatively small increase in sugar, I doubt that Candida is the cause of the problem.

    So although the experience of taking D-Ribose has been less then pleasant, Because D ribose it is a product that people with diseases that cause hypoglycemia shouldn’t take, because it will make them sicker, it gives what might turn out to be a very useful clue, to help find what is causing at least a part, if not all of your health problems, which may turn out to be very treatable.

    My opinion is that you should stay off the D ribose, and instead go and see your doctor, and get them to do the tests for hypoglycemia. For UK patient this always seems to come with the problem of UK GPs seeing people who have been diagnosed with ME (often Misdiagnosed) as having a psychiatric disease. You can take the information on this site to your doctor about the blood sugar lower affect of D ribose, in diabetics and people with liver disease see http://www.bioenergy.com/pdf/mf/sl/Ribose%20&%20Blood%20Sugar/Ribose_Blood%20Sugar_Science%20070303.pdf

    Not sure if the situation has changed but many labs have been using out of date reference ranges for tests for hypoglycemia.

    The fasting plasma glucose should be <100 mg/dl (5.5 mmol/l).

    Postprandial plasma glucose should be <140 mg/dl (7.7 mmol/l)at 30-minute, 60-minute, 90-minute, and 120-minute. See http://www.bmj.com/rapid-response/2011/11/01/myth-chronic-fatgue-syndrome this test is explained here http://en.wikipedia.org/wiki/Postprandial_glucose_test

    If these tests show Hypoglycemia, then the next step is finding the cause and treating it.

    Hope this helps

    All the best
    Lotus97 likes this.
  14. Sasha

    Sasha Fine, thank you

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    Hi rlc - that was really good of you to write such a detailed post!

    I didn't feel that my symptoms were those of hypoglaecemia, though - no weakness or shakiness - I just felt as though someone had taken my batteries out. It felt like an absence of energy.
  15. Little Bluestem

    Little Bluestem Senescent on the Illinois prairie, USA

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    I take 100 mg or 1/4 teaspoon of Ribose 4 - 5 times/day, always with food or it will give me low blood sugar. It does not make me feel more energetic, but I tire less quickly/have more stamina (for a person with ME).

    I take Nature's Plus which says that it contains RiboCell, a trademark of Nutratech, Inc.
    rosie26 and Sasha like this.
  16. rlc

    rlc Senior Member

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    Hi Sasha, re

    Hypoglycemia symptoms depend on the severity of the hypoglycemia, it will cause fatigue (absense of energy) the more severe symptoms like sweating and shaking are normally associated with severe hypoglycemia, it is also possible that if you have a disease that is lower your blood sugar, that the sudden increase in your sugar levels with D ribose is agrevateing the underlying disease.

    Like I say low blood sugar is the only known reason that I have ever seen for bad reactions to D ribose, so it could turn out to be a important clue, so if your doctor will test your glucose levels (which they should have done anyway), if they are high this should then lead to finding the cause and treatment.

    If your glucose levels are normal, then I guess medical science has missed something.

    All the best, Sasha hope feel better soon.
  17. Sasha

    Sasha Fine, thank you

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    Thanks - something to look into!
  18. snowathlete

    snowathlete

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    (Accepting that mitochondrial dysfunction isn't fully proven in ME/CFS yet) Isn't it already widely accepted that mitochondrial dysfunction can lead to oxidatative stress? And therefore if we have mitochondrial dysfunction than suplementing with ribose could, perhaps, lead to an increase in that damage. Which would make you feel pretty awful.
    MeSci likes this.
  19. Lotus97

    Lotus97 Senior Member

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    Hmmm. My fasting glucose was 87, but the lab says the range was 74-106. What's going on? I've had hypoglycemic symptoms for the past 15 years, but every time I was tested they told me I wasn't hypo. In the past the doctors didn't tell me the test results. Thankfully my doctor sends me print-outs of all me tests. Doesn't do me much good though if the reference ranges are bogus. Is this a common problem among tests' reference ranges? Or is the hypo one an anomaly?
  20. Sushi

    Sushi Moderator and Senior Member Albuquerque

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    I think 87 is fine for fasting glucose. The range my lab gives is 60 - 100. My morning, fasting glucose is normal but when I did the 3 hour glucose tolerance test, it dropped to 4o. You really need more than morning, fasting glucose to check for hypoglycemia.

    Sushi

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