Sorry to hear that GSE didn't help you. I did a fair bit of reading up on GSE and thought that the evidence was reasonably good that it was effective, at least in vitro, and I think that at least some manufacturers give assurances that their product is not contaminated. There is a paper here on in vitro tests done with a pure product: http://hrcak.srce.hr/file/26006 I wonder whether some of the accusations come from pharma companies wanting to discredit natural medicine? I don't know - just wondering. I haven't had much in the way of gut testing, but have had problems on and off since childhood. I was rushed to hospital as a child with severe gut pain that was thought to be appendicitis but wasn't; however, my colon was found to be inflamed. The only other test I can think of was a FOBS test a few years ago (negative). I lost what little faith I had left in doctors in 2010 following hospitalisation due to severe hyponatraemia. The medics have consistently refused to take my views on board about possible causes, and insisted that I must have been overhydrated, when test findings show the opposite. D-lactic acidosis can cause hyponatraemia.