Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
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Cytokine profiles of chronic fatigue syndrome and multiple sclerosis patients

Discussion in 'General ME/CFS News' started by Daisymay, Oct 3, 2014.

  1. Daisymay

    Daisymay Senior Member

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    http://www.sciencedirect.com/science/article/pii/S1043466614004165


     
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  2. Daisymay

    Daisymay Senior Member

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    The above is a abstract being presented at the International Cytokine and Interferon Society to be held in Melbourne in October:

    http://www.cytokines2014.com/
     
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  3. user9876

    user9876 Senior Member

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    Perhaps the interesting bit is

    The CFS patients were diagnosed using ICC. The sample sizes are small.

    I've no idea what different cytokines do!
     
  4. Denise

    Denise Senior Member

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    NK17 likes this.
  5. Jonathan Edwards

    Jonathan Edwards "Gibberish"

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    I suspect there is no full article, since this is due to be published in a volume dedicated to conference abstracts. That usually means that this is a preliminary communication in abstract form only.

    There is a rather embarrassing technical problem in the abstract in that some p values are given as 0.000! Probabilities are never zero in this context. I wonder if the senior authors checked the abstract! I think there may also be a Bonferoni correction problem. It looks as if the authors did at least 28 calculations that address the question of whether CFS has a specific cytokine profile in comparison to normal and MS. That means that we may have to think about multiplying all the p values by something like 28 (a Bonferoni correction). It is not as simple as that but I would wait to see a full peer reviewed report before passing judgment on these findings.
     
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  6. Denise

    Denise Senior Member

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    Thank you for highlighting these concerns.
    I agree that it is wise to exercise caution before passing judgment on these (or any) findings.
     
  7. MeSci

    MeSci ME/CFS since 1995; activity level 6?

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    Mady Hornig has said that pwME have high levels of interferon-gamma (IFN-γ) in the first 3 years only. I wonder how long the subjects in this study had been ill.

    Interferons can cause low mood among other things.
     

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