1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
Phoenix Rising Adds Two New Board Members
Mark Berry introduces the new President of Phoenix Rising, Dr. Gary Solomon, and welcomes Professor Jonathan Edwards to the Phoenix Rising Board of Directors.
Discuss the article on the Forums.

cytokine effects

Discussion in 'Pain and Inflammation' started by Ivana, May 29, 2012.

  1. Ivana

    Ivana Senior Member

    Messages:
    112
    Likes:
    10
    hi all

    sorry if this question has been asked before.. But what are the symptoms of cytokines? I get neurological problems, followe by a feeling of being freezing cold, then muscle pain, then overwhelming fatigue which puts me out for ages. Ive been told these are the effects of cytokines and that ldn will help. Willl it? Also, what does increased il-8 and decreased tgf beta1 mean?
  2. xrunner

    xrunner Senior Member

    Messages:
    559
    Likes:
    225
    Not sure.
    However, in this talk http://forums.phoenixrising.me/inde...nfectious-disease-syndrome.17676/#post-269445
    Dr Horowitz explains cytokines and things that help reduce inflammation. The talk is about Lyme disease but the concepts apply beyond that.
    He says that shutting down NF-kB (a kind of switch in the nucleus of the cell, if I got this right...) helps reduce cytokines production and inflammation. At some point, he talked about LDN also for pain and neurological issues (I think).
  3. lnester7

    lnester7 Seven

    Messages:
    1,222
    Likes:
    1,097
    USA
    which Cytokines specifically? as I understand they do different things. I have IL2b, IL10 high, rest is normal.
    TnfI and TNFII low and very low.
  4. heapsreal

    heapsreal iherb 10% discount code OPA989,

    Messages:
    7,220
    Likes:
    4,524
    australia (brisbane)
    IL6 is a commonly elevated inflammatory cytokine in cfs and is linked to sleep dysfunction. DHEA is suppose to be effective to some degree against IL6.
  5. Sushi

    Sushi Moderator and Senior Member Albuquerque

    Messages:
    6,878
    Likes:
    5,718
    Albuquerque
    IL 8 also seems to be a marker for inflammation

    Sushi
  6. alex3619

    alex3619 Senior Member

    Messages:
    7,185
    Likes:
    11,250
    Logan, Queensland, Australia
    Cytokine research is very complicated. One of the issues is we still don't have a complete picture of what they are or how they work. We know a lot, but we keep learning more. Cytokine research is mostly a modern science, and still growing. I gave up trying to get a good grasp of cytokines in about 2002 when it became apparent that I would have to spend hundreds of hours going through arcane journals to understand even a few of them. There was no convenient overview that was anything like right. Decent textbooks on this didn't exist back then, although they might now as I have not looked. A cytokine researcher will have taken the time to do that background reading, and grappled with the subject in experiments. If you can find a good text on this it might answer some of your questions, though its also likely to be difficult to understand unless you have a good background in molecular biology. Bye, Alex
  7. heapsreal

    heapsreal iherb 10% discount code OPA989,

    Messages:
    7,220
    Likes:
    4,524
    australia (brisbane)
    cytokines i think also have a short life as well, is that right alex?

See more popular forum discussions.

Share This Page