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CYP2C19

Discussion in 'Genetic Testing and SNPs' started by maryb, Jan 5, 2014.

  1. maryb

    maryb iherb code TAK122

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    Can anyone point me to where I can find information about this cytochrome on my 23 and me results.
    My husband is on clopidogril an anti blood clotting med - it seems people who are poor metabolizers are at a high risk with this drug. I will get him to do the test if I can sort my own out.
     
    Last edited: Jan 6, 2014
  2. Helen

    Helen Senior Member

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  3. maryb

    maryb iherb code TAK122

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    @Helen
    thanks for that - I think it was a similar site I drifted onto last night. Of course I've just read that a 'leading' cardiovascular man in the UK of course said its easier to test for platelet function than to do this test. You see its all about cost here to the NHS not about 'whats best for the patient' so if you don't have regular platelet functioning tests - tough........
    I must admit I'm totally baffled by cytochrome/enzyme/snp's - I don't know what I'm doing but just feel as my husband hasn't been well on this drug he should know more about it, he's a typical man - practical stuff he's great but anaythig to do with his health - nah........
    And of course I'm too sick to be of much help really.
     
  4. maryb

    maryb iherb code TAK122

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    anyone know what this result on my detox profile means?

    CYP2C19*17 CT yellow+/-
     
  5. Sea

    Sea Senior Member

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    It means you have one copy of variant 17 of CYP2C19. You can google that variant to see what effects it has on metabolising certain drugs and toxins.

    http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2009.03578.x/full

    Results for the gene are here
    https://www.23andme.com/you/explorer/gene/?gene_name=Cyp2c19

    http://scholar.google.com/scholar?q=CYP2C19

    http://scholar.google.com/scholar?q=CYP2C19*17&btnG=&hl=en&as_sdt=0,5

    SNPedia is quite informative on this gene too
    http://snpedia.com/index.php/CYP2C19
     
  6. maryb

    maryb iherb code TAK122

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    @Sea
    Thanks so much for all those links I really appreciate it - I looked at one of them and it seems that it not a problem. Well that's for me anyway - still think it may be worth getting my husband to do the 23and me test. I'm not sure how much info they give with it now.
     
  7. Sea

    Sea Senior Member

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    I find the value in the 23andme test to be in the raw data that I can research rather than the reports that they give so it didn't worry me to hear they won't be giving health reports for now. The real problem is that they're changing to a new chip which reports on around 600 000 snps instead of the over 900 000 they've had until now. We don't yet know which ones will be left out.
     
    Valentijn likes this.
  8. maryb

    maryb iherb code TAK122

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    @Sea
    that's very interesting, not for our benefit then....
     
  9. Sea

    Sea Senior Member

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    @maryb no, I can't see how it would be for our benefit even though 23andme are trying to say it is. I think it's about streamlining and profit, about being able to run a greater volume of tests at the same time. There will be some additional snps that are not on our version but we don't yet know what those are either
     
    maryb likes this.

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