Have been on Cymbalta for a few days after experiencing a huge crash that had me in severe pain/sleeplessness for over a week. It is working amazingly. Pain in my legs and back is a fraction of what it had been and even less than it was before I had the crash. Headache pain much better although I still usually end up taking some ibuprofen during the day. After reading suggestions from other forum members, I am taking at night because it makes me very groggy. Can actually get me to fall asleep without other sleep meds. However, I wake a few hours later and need to take something else to stay asleep. Am experimenting with going back to ambien in combination rather than trazadone or Seroquel because my medical advisor is concerned about me taking many psych meds in combination. I am now taking 20 mg Prozac in the am and 30 mg Cymbalta in the pm. He thinks I should go to just Cymbalta and not take in combination with Prozac. I'm a little worried to taper too quickly. I had been on 40 mg Prozac and was reducing by 10 mg every month or so. Depression is still a big problem for me. Would appreciate any thoughts/experiences.