I have Lyme Disease. I have the following mutations: MTHFR A1298C homozygous CBS A360A homozygous NAT2 K268R homozygous I take: 2 ml of hydroxycobalmin - 2 intramuscularly injections / week full dose of http://www.seekinghealth.com/optimal-multivitamin-240-vegetarian-capsules.html / daily, 4 capsules 2 times a day I feel great for roughly three weeks, tons of energy. Night and day difference with how I usually feel. After about three weeks, each time I take my capsules, I feel very weak, like a detox. I also get more and more depressed each time I take those pills. When I take 100 mg of niacine, I start to feel better again. I then wait a week, 10 days. something like that. I feel great again for three weeks and bam, same thing happens again. I also had the same experience with NTFactor (ATPFuel from Researched Nutritionals). But instead of three weeks it was three days. Is this over/under methylation? Just the methylation cycle starting up again and I need to ride it out? Something that gets depleted?