Between doctors and supplements I bet I've spent over $50,000 trying to cure this. I'm gonna write an ebook on it I think. This disease has taken 4 years of my life from me. Let me just say that it is more complex than just lactic acid bacteria overgrowth. Though for me that was definitely an element. I'll outline the problems right here. I want to say that there are probably 100 ways to induce CFS, yet in most cases all of these elements are present. 1) Abnormal High Calcium Ion Currents In the Body as seen in Autism (Causes the Hyperactive wired but tired feeling) http://www.ncbi.nlm.nih.gov/pubmed/7968720 2) Abnormal Gut Flora and Gut Inflammation (Possibly High Amounts of Lactic Acid Producing Bacteria) If you look at cows fed a high grain diet with mostly lactic acid producing bacteria in them their intestines get charred(literally looks like they have been burned by the lactic acid generated from the bacteria fermenting the grains) and their intestinal villi get destroyed. http://www.ncbi.nlm.nih.gov/pubmed/22281935 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964729/ 3) Low DHEA, Testosterone, or Other hormones like Cortisol and Aldosterone and Pregnenolone (Any possibility of Low Hormones is Possible so you must have them all checked.For men at least I recommend 100mg of DHEA per day and 200mg per day on exercise days. Friend has done labs and 300mg a day puts him in the top lab range so the only way to tell is to test your levels after supplementation. 4) The Brain's Reward Center is Malfunctioning from Toxin Exposure and or Depressed from Sickness. The only way yet again to fix this is with a specific nootropic substance that has all the effects of say a prescription ADHD stimulant but none of the associated side effects. This may naturally heal itself but I'm not sure without the supplement. http://www.sciencedaily.com/releases/2012/04/120424142109.htm 5) Serotonin Dysfunction It is funny because in chinese medicine, fatigue is damaging to the digestive system. This disease is a vicious circle. As long as the top problems persist, there will not be a cure. Many of you don't believe there is a cure. Well, considering I was once normal I refuse to believe that. Everyone gets exposed to viruses and pathogens. Not everyone gets chronic fatigue. Therefore something must be causing the chronic fatigue. I am writing the ebook now and 100% of it is backed by scientific studies off pubmed. This is the core of the healing, though I will not mention any specific supplements in this thread that ARE necessary to fix the problem 1,2, and 3.