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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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Hi Rand,
I never take any knotweed later than early afternoon for that reason.
It's only recently. When I first tried it, years ago I wasn't too well, it didn't have any effect on my sleep.
Now it does.
I think tolerance builds to anything, i think if an amino acid precursor stops working then just stop it for a week or 2, maybe longer if needed and then use again. I also think just using these things occassionally helps as well. I also think making sure you have good adrenal hormones like dhea, good thyroid etc is important to getting neurotransmitter levels right. Increasing neurotransmitters with low hormones might be like whipping a dead horse. Pregnenolone can also help with different neurotransmitters but these adrenal hormones can be tricky to adjust in cfs/me people and dosages alot lower then is normally recommended should be used. certain herbs can be useful but i think sometimes these also can be like whipping a dead horse, need to have good dhea, cortisol etc levels i think if using these.
cheers!!!
Hi Heaps
Makes total sense and I guess I was that dead horse.
Hi all
It's been awhile since I have posted and I am still dealing with my atypical low Dopamine/NE depression and I have some questions if anyone can answer. I'll first say that I have tried Curcumin in the past but maybe I was not taking a high enough dosage of it to have an effect. I now started taking a higher dosage and although I feel a bit better my first question concerns the safety of taking higher dosages of it to see if I can get more of a AD response as I know that curcumin has some MAOI properties. Also to let you know stimulants work for me but don't want to become a stim junkie.
Also..sleep deprivation also works for me but obviously not a good solution.
First I'll preface by saying I seem to have a very high tolerance for supplements as I have tried many different ones in the past. I'm taking the Triple Strength Curcumin from Vitamin Shoppe. Each cap is 95% curcumin..900 mg along with 5mg of bioperine. I started taking 2 per day..no real effect. Upped it to 3..got more of an effect. Upped it to 4 per day and got even more of an effect..but I feel like I need to push it more. Is it even safe for me to take 3 per day let alone 4 or even more if I want to push it? If not, can anyone suggest anything else I can throw into the mix without going too high on the curcumin?
I've tried Resveratrol Sustain Alpha LV before and actually got a good response from that but then started getting the achilles heel pain that I understand others have gotten. If I needed to, is taking Resveratrol in combination with Curcumin ok to take together? Maybe by combining them and keeping the Resv dosage lower I can possibly avoid the achilles heel pain.
I'll also let you know that Licorice is a help for me as well. I understand you have to cycle it, but I was more afraid of taking it more for the long term because of it's estrogenic effects. Are any of these 3 safe to take in combination or can anyone suggest anything else I can try? Just to let you know..if you suggest something I've probably tried it already but give it a go anyway LOL.