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Cryptovirus found in 96% of ME/CFS patients (old research news from 2006)

Discussion in 'Latest ME/CFS Research' started by Bob, Aug 14, 2010.

  1. Bob

    Bob

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    I think I've come to the conclusion that Cryptovirus is just another very common virus that easily infects people with ME, just like HHV-6 does.

    Although it was found in a high percentage of ME/CFS patients, these patients were all based in the same locality, South East Queensland, and there doesn't seem to have been any healthy control samples tested for the same virus. As far as I can see, a paper on Cryptovirus was never published, so the research does not have a particularly solid basis.

    Cryptovirus and the SER (swine) strain of PIV-5 share some identical protein strands of their genome, so it is possible that Cryptovirus is a human isolate of the SER strain, meaning that Cryptovirus would be a zoonotic virus (a species crossover). But it hasn't been confirmed that Cryptovirus is the same as SER in anything that I've read and it seems to be speculation rather than fact.

    It seems probable that Cryptovirus is a human variant of PIV-5, as there has been research published which describes Cryptovirus as a human variant of PIV-5.

    At the very least, Cryptovirus sits within the Rubulavirus genus (virus categorisation) along with PIV-5 and mumps, and so at the very least, it is very closely related to PIV-5 and mumps.
  2. Bob

    Bob

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    Rusty, I don't know how widely the following is agreed upon, but it might be reasuring for you (taking into account my previous post)...

  3. RustyJ

    RustyJ Contaminated Cell Line 'RustyJ'

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    Yeh, sorry. That was a mistype. Thanks for the pick up. It is difficult to offer a line of reasoning when my brain does things like that.

    Re the status of PIV-5 as a co-infection, I want to believe you. It is probably the case. You've done some good work here thanks. I hope more people read it.

    Just mention that in the Queensland study, Robbins was referred the more affected patients (this is how cohorts are skewed). Since he found a virus in the spinal fluid in quantities that reflected the degree of incapacity of the patient, he jumped to the conclusion that it was the cause, in the absence of any evidence of another virus (eg XMRV).

    Does anyone think it is a good idea that the post no of a quote be automatically added, say alongside who the quote is from? I am sure it is possible.
  4. Bob

    Bob

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    Hi Rusty,
    Look in the quote box, above, and just to the right of your name, you'll see a tiny blue box with two white arrows in it... If you click on that then it takes you to the original post that's quoted... You can test it with your quote, above.
    It's a very handy little function.
    I've no idea how i discovered it! Most people probably don't know about it!
    Bob
  5. Bob

    Bob

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    I can't help feeling that, if XMRV turns out to be as significant as i think it will, then we might find that people with secondary infections such as HHV-6 and Cryptovirus might have more complex symptoms than those with only XMRV.

    I think XMRV might work a bit like HIV where secondary infections are able to take hold because of the primary infection (HIV or XMRV). The secondary infections cause so many complications for AIDS patients.

    It's interesting to note that Dr Lerner has had success treating ME/CFS patients with anti-virals, but only if they have certain specific secondary infections (such as HHV-6), which respond to the antivirals that he uses. This suggests that secondary infections play a part in causing symptoms for ME/CFS patients. Maybe if the XMRV is treated first then the secondary infections will clear up anyway. (I'm assuming that XMRV is the primary infection for the sake of discussion).
  6. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    Exactly bob, it seems that multiple infections are much more harder to treat aka lerners study, but also if a retro is the enemy its going to reactivate all these other normally benign infection, just like in hiv patients
  7. taniaaust1

    taniaaust1 Senior Member

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    wow thanks for that info.. i'd never even noticed that little box.
  8. taniaaust1

    taniaaust1 Senior Member

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    Seems so much confusion is around this subject.. im not willing to just reject that there could be something in this. i think more investigating should be done.. yeah it doesnt cause illness in MICE!! who knows if that means it wont cause symptoms in us.

    Not sure which one it could of been.. soo many different pathogens have been connected to CFS/ME and Australia has done a lot of different studies (usually very small ones) here.

    One study here found that half of those with CFS/ME had rickettsia. (that was an informal one done by a Sth Australia CFS specialist).

    The queensland subgroup has ones with CFS who Ross River virus has been the triggering illness for the CFS/ME. 10% who get Ross river virus end up with CFS/ME.

    i think people need to realise that not all of Australia is not a tropical climate.. but yeah the Queensland state of Australia is.

    My own state's climate of Sth Aust is very similar to California.
  9. RustyJ

    RustyJ Contaminated Cell Line 'RustyJ'

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    It takes me back to the first page of this thread only. What am I doing wrong?

    Edit: Working now. Brilliant!
  10. Bob

    Bob

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    Yes, I agree with you Tania... I think that PIV-5 might cause some symptoms in people with ME/CFS, and it might trigger ME, just as other pathogens are thought to... But as far as I've worked out, PIV-5 is a very common virus, like HHV-6... And it's in the same family of viruses as mumps and measles.

    For me personally, I think that XMRV would explain all of these pathogens which our community gets, including Lyme disease, as being secondary infections to XMRV... I guess we just have to wait and see for the answer to that one.

    Thanks Tania... that's interesting...
    I'm sure that the lecture I heard was about one of those pathogens that you've mentioned... Rickettsia rings a bell for me... It was a couple of years ago now, so I can't remember.

    I know that Australia isn't entirely tropical... I visited your beautiful country, for a month, exactly a year before I became ill... I visited Sydney, stayed in Brisbane and toured Queensland, up to Cape Tribulation.

    Maybe I picked up a virus in Australia, and that contributed to me getting ME? But I think it was more to do with me working in a hospital and getting Hep B vaccinations, and picking up Cold Sores for the first time ever from the filthy ward that I was working in.

    I loved being in Australia, and I had a lovely time, visited some amazing places and saw some amazing things, and had some wonderful experiences.
    The Great Barrier reef is the most stunningly beautiful experience that I've ever had... It was unbelievably beautiful, and completely blew me away. :Retro smile:
  11. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    i think when it comes to all these different viruses, they are all opportunistic due to a dysfunctional immune system( maybe caused by retrovirus), a normal immune system keeps them in check but a crappy one cant supress these viruses and then they reactivate and can make the immune system more dysfunctional or just wear out the immune system. I think treating these bugs can help reduce viral/bacterial load, helping reduce the stress on the immune system, therefore it has the energy to supress other bugs not covered by anti-infectious meds that are taken. But personally we need something thats going to bolster our immune system and by most studies involving our immune systems its our NK cells that need attention. This is where ampligen comes into play as well as immunoglobulins and possibly immunovir. I think treatment is going to be a kitchen sink treatment, specific drugs that are involved in that particular person then the immune enhancing stuff ie ampligen, immunoglobulins etc.
    August59 and merylg like this.
  12. Bob

    Bob

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    I agree with everything you've said there, heapsreal.
    August59 and merylg like this.
  13. forgottenstar

    forgottenstar

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    If anyone wants to contact him regarding this, his name comes up as a professor at Arcadia University. I personally am still learning the terminology used on this site and I am relatively confused, otherwise I would contact him myself.

    robbinss@arcadia.edu
  14. Bob

    Bob

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    That's a good find, forgottenstar...

    Rusty... I think it might be totally appropriate for you to send Dr Robbins a message, do you think? If it's something you'd like to do.
    Or if you'd like me to send him a message, then please let me know.

    forgottenstar, if you'd like to ask any questions at all, about anything, then please feel free to ask, either on the discussion thread, or via private message, and I'll do my best to answer.

    Bob :Retro smile:
  15. RustyJ

    RustyJ Contaminated Cell Line 'RustyJ'

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    Bob, that's very generous of you. Would it be possible for you to make initial contact with some science-based questions? My communication skills have been severely limited by CFS. I don't trust myself to ask the right things without getting it all confused. Maybe if he has opened up debate, and settled some of the issues, I can ask a more personally directed question or two about the Brisbane cohort.

    I hope there are others out there getting something out of the work you are putting in here :Retro smile: - (first use of a smiley face, yeehaa!)

    Thanks a bunch, forgottenstar.
  16. Bob

    Bob

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    Rusty, let's discuss this privately, so maybe we can draft an email together, and get some answers for you... I'd be happy to help you draft a letter to get the answers that you need... I'll get in touch with you tomorrow, as I've got to go to bed now... Keep an eye on your private messages tomorrow afternoon. (oh, i'm talking uk time... it's midnight here now, so i'll be in touch within 12 hours or so). Night.

    Thanks Rusty :Retro smile:
  17. RustyJ

    RustyJ Contaminated Cell Line 'RustyJ'

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    Excellent :Retro smile::Retro smile:
  18. wastwater

    wastwater Senior Member

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    I had upper respiratory tract infection and Haemophilus parainfluenzae isolated from my throat after a suspected measels vaccine hospitalised me aged 18 months.Is this the same thing
  19. Hip

    Hip Senior Member

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    Dr Chia's research using stomach tissue biopsies to identify the viruses present in ME/CFS patients came back negative for varicella-zoster, parainfluenza viruses, adenovirus and respiratory syncytial virus, but of course strongly positive for enteroviruses.
  20. Hip

    Hip Senior Member

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    No, Haemophilus parainfluenzae is a bacterium, not related to parainfluenza virus.
    RustyJ likes this.

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