I have a serious situation, and nobody can help me so far. The emergency room's can't do anything, neurologist, endocrinologist, cardiologist, etc. have been unable and unwilling to assist me. I cannot explain in words how desperate I am. I'm at a 9.9 out of 10 on the scale of human suffering a person can even tolerate. I'm very desperate, so please, I beg of you, give me a chance and see if you think you can help me. I know I posted before, but the post got so off track with methylation (which didn't seem to help), and I wanted to give this a fresh start and fresh set of eyes. Simple story: I've had POTS Syndrome my entire life. Starting at age 13, I became the most sensitive person to the effects of herbs & meds. 1mg was as if I took 1,000mg. It was insane. It was impossible to live like this having medical reactions to herbs soaps, shampoos, etc. Age 19, discovered (through luck and a recommendation) that Ashwagandha would give me temporary relief for my sensitivities. I had to take it every single day to not be reacting to all the herbs in soaps, shampoos, supplements, etc. Age 20 (approx), discovered that Chamomile did the opposite of Ashwagandha and made me more sensitive, temporarily. So, in other words, if I took Ashwagandha & Chamomile together, they were counteracting each other 1 to 1. Age 24, I began using Choline Bitartrate (and occasionally CDP Choline) instead of Ashwagandha after reading that Ashwagandha affects Choline receptors. Choline caused a permanent shift in my sensitivities, even after I stopped using them. It caused me to be left with extreme fatigue, shortness of breath, overall pain, brain fog, and non-responsive to herbs/meds even after discontinuing and it has not improved on it's own in years. nAChR = Nicotinic Acetylcholine Receptor Possible theory so far: POTS is caused by a partially blocked or inhibited parasympathetic nervous system. My theory is that Ashwagandha worked since it is an acetylcholine receptor agonist, and Chamomile did the opposite because it is an acetylcholine receptor antagonist. And obviously, Choline directly did something long-term, but I don't understand WHAT. I've got to find the reverse feedback mechanism that tells the body the parasympathetic nervous system is over-active or under-active to get my life back. I feel so bad 24/7. I WILL BE FOREVER INDEBTED TO WHOMEVER CAN HELP ME SOLVE THIS EQUATION AND GET SOME RELIEF!!!!