Well there goes what ever understanding I thought I had. So if we are looking at genetic genie for example, you are saying just because the +/+ is red doesn't mean it is defective (mutation not expressing itself properly resulting in functional impairment)? How in the heck can we make sense of the genotype info we are getting? So your panels are created identifying the most likely genotypes associated with a condition based on a study and further identifies any homozyg/heterozyg that has been specifically identified as defective (indicated by an !)?? Am I getting it right? I think a lot of people are taking +/+ / RED to be a sure sign of defunct gene expresion.