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Creatine Synthesis Requires SAM-e As A Co-Factor

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Wayne, Nov 16, 2013.

  1. Wayne

    Wayne Senior Member

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    Ashland, Oregon
    This is the title of a slide from a methylation video (link below) by Dr. Benjamin Lynch (thanks @Caledonia for posting about this great video). At the 16:50 minute mark, he begins to expound on how important SAMe is for so many critical bodily and cellular functions.

    After 2-3 minutes, he begins to expound on how creatine synthesis requires so much SAMe, and how being deficient in creatine crowds out other critical SAMe needs in the body. Watching for 5 minutes from 16:50 to ~22:00 was very helpful for me.

    I've always done well with creatine, but have not always taken it regularly. I now anticipate supplementing even more, especially since it's a relatively inexpensive supplement (MUCH cheaper than SAMe).
    .................................................................

    “Creatine synthesis is estimated to consume between 40 and 70% of available methyl groups provided by SAMe”

    Folate and Methylation Defects and Metabolism in 2013: Clinical Breakthroughs (Part 1 - Presentation)
     
    Last edited: Nov 16, 2013
    Rand56 and heapsreal like this.
  2. Soundthealarm21

    Soundthealarm21 Senior Member

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    Dallas, TX
    I'm going to give his MTHFRade a try. Combines electrolytes, Vitamin C powder, Ribose, and Creatine together.
     
  3. caledonia

    caledonia

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    @Soundthealarm21 I do something very near to that without creatine. Sounds like it might be something to try.

    Although I'm wondering, if more SAMe is then available, then would it cause metal detox? I'm struggling with that right now from trying out a Yasko's new All in One multi, which has a little of everything in it, including SAMe. It's probably going to be 6 months or so before I'm fully detoxed.
     
  4. Soundthealarm21

    Soundthealarm21 Senior Member

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    Dallas, TX
    Although I'm wondering, if more SAMe is then available, then would it cause metal detox? I'm struggling with that right now from trying out a Yasko's new All in One multi, which has a little of everything in it, including SAMe. It's probably going to be 6 months or so before I'm fully detoxed.[/quote]

    That's a good question to bring up. Maybe go over to Lynch's website and post that question, or on facebook. Or if Yasko has a platform where you could ask.

    Logic would make me think that if more SAMe is available then more gets converted to SAH which leaves more to go down CBS pathway and eventually end up as glutathione and detox. But I have absolutely no research to back that up.

    Try and get your question answered and then proceed with caution.
     
  5. leela

    leela Slow But Hopeful

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    Couchland, USA
    My own takeaway from the video was that viruses are screwing a bunch of stuff up, and they are binding metals, and that betaine+creatine would help the body go after the virus situation. (I may have that all wrong now, my brain is incredibly swelly lately.badly.) So I'm going to start on creatine and TMG and see what happens. I've got binders/moppers on hand, and vitamin C, and liver support. We shall see.

    I guess this popped out at me because I've had consistently low creatinine for years , and I'm feeling so viral atm.
     

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