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Coxsackieviruses causes chronic valvular heart disease

Discussion in 'Immunological' started by Emootje, Sep 27, 2010.

  1. Emootje

    Emootje Senior Member

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    1 DePasquale NP, Burch GE, Sun SC, Hale AR, Mogabgab WJ.Experimental Coxsackie virus B4 valvulitis in cynomolgus monkeys.Am Heart J. 1966 May;71(5):678-83.

    2 Burch GE, Chu KC, Soike KF.Experimental coxsackievirus B4 valvulitis in squirrel monkeys.Exp Mol Pathol. 1982 Jun;36(3):414-22.

    3 Polubentsova EI, Lavrova IK, Stulova MA, Prokhorova IA.Functional study of the heart valve apparatus by 2-dimensional Dopplerechocardiography in rats with experimental endocarditis caused by Coxsackie B3 viruses]Kardiologiia. 1993;33(10):64-71, 6-7. Russian.

    4 Ward C, Ward AM.Letter: Virus antigen in valvular heart-disease.Lancet. 1974 Apr 20;1(7860):755-6.

    5 Li Y, Pan Z, Ji Y, Peng T, Archard LC, Zhang H.Enterovirus replication in valvular tissue from patients with chronic rheumatic heart disease.Eur Heart J. 2002 Apr;23(7):567-73.

    6 Chandy KG, John TJ, Cherian G.Coxsackieviruses and chronic valvular heart disease.Am Heart J. 1980 Oct;100(4):578-80.

    7 Chandy KG, John TJ, Mukundan P, Cherian G.Coxsackie B antibodies in "rheumatic" valvular heart-disease.Lancet. 1979 Feb 17;1(8112):381.

    8 Burch GE, Harb JM, Hiramoto Y.Human valvular disease in coxsackie B4 virus infection. A light,immunofluorescent and electron microscopic study.Cardiology. 1974;59(2):83-91.

    9 Burch GE, Sun SC, Colcolough HL, Sohal RS, De Pasquale NP.Coxsackie virus valvulitis and myocarditis observed at routine autopsy.Experientia. 1967 Dec 15;23(12):1041-2.

    10 Pongpanich B, Boonpucknavig S, Wasi C, Tanphaichitr P, Boonpucknavig V.Immunopathology of acute rheumatic fever and rheumatic heart disease. Thedemonstration of Coxsackie group B viral antigen in the myocardium.Clin Rheumatol. 1983 Sep;2(3):217-22.
  2. Sing

    Sing Senior Member

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    What is chronic valvular heart disease? Is this the same thing that Dr. Cheney finds in his echocardiograms? Or different? Please explain in more ordinary terms what this is about--

    Thanks!
  3. Timaca

    Timaca Senior Member

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  4. Emootje

    Emootje Senior Member

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    Valvular heart disease is any disease process involving one or more of the valves of the heart.
    The heart has four valves.
    1. Aortic valve
    2. Mitral valve
    3. Tricuspid valve
    4. Pulmonary valve
    Valve disease can manifests itself by narrowing of the valve opening (stenosis) or/and by not closing properly (regurgitation)
    So..valvular heart disease could manifest it self with one or more undermentioned valve abnormalities:

    • Aortic valve stenosis
    • Mitral valve stenosis
    • Tricuspid valve stenosis
    • Pulmonary valve stenosis
    • Aortic regurgitation
    • Mitral regurgitation
    • Tricuspid regurgitation
    • Pulmonary regurgitation
    Coxsackie viruses could mimics a rheumatic valve disease resulting in Mitral valve stenosis and/or Aortic valve stenosis or/and Aortic regurgitation and/or Mitral regurgitation and/or Tricuspid regurgitation.

    In my case:
    In 1992 I started to suffer from chronic nausea with chronic throat pain and chronic stuffy nose. (probably a chronic enterovirus infection)
    In 2001 I developed Mitral regurgitation, Aortic regurgitation and Aortic stenosis. My cardiologists could not explain my valvular disease. I'm sure it's because of my chronic enterovirus infection

    For more enterovirus/valvular heart disease information:
    http://eurheartj.oxfordjournals.org/content/23/7/567.full.pdf

    About dr Cheney:
    Cheney finds something else on his patients echocardiograms. He finds a diastolic dysfunction (abnormality in the heart's filling during diastole) that is according to him related to low ATP in the heart.
  5. Emootje

    Emootje Senior Member

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  6. Sing

    Sing Senior Member

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    Thank you so much, you two. I am going to save this information. I think this is what got my CFS going--an enterovirus infection--maybe in combination with XMRV. I haven't gotten tested yet but am circling in closer.

    Sing
  7. Michael Dessin

    Michael Dessin Senior Member

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    Yea, I think mine is enteroviral origin as well...coxsackie B has been an issue for me ...havent tested for XMRV as of yet
  8. Sing

    Sing Senior Member

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    The textbook on ME/CFS from the early 90's which Dr. Hyde edited, featuring chapters by a host of experts at that time, wrote that their hypotheses about causation centered on two possiblities: enteroviruses and retroviruses. That is where suspicion lay most strongly--
  9. Boule de feu

    Boule de feu Senior Member

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    Thank you Emootje. Thank you Sling for your MP on this. I will have to check if the infectious disease specialist has already check for coxsackie viruses. The nausea and the sore throat could be explained by this.

    If you would have a choice of seeing one of the world's CFS specialists which one would you choose? and why? Would Dr. Cheney be the best choice ? (This would make a good thread - we should ask everyone!). =-)
  10. Emootje

    Emootje Senior Member

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    I think XMRV/MLV with a co-infection is the best hypothesis for this disease. It explains why different (viral) triggers resulted in the same syndrome.
    For patients with an enteroviral trigger it looks something like this:

    CFS..JPG

    Gamma Retrovirus mono-infection: No symptoms
    Gamma Retrovirus with co-infection: ME symptoms

    CFS2..JPG

    NF kappa beta (inflammation) stimulate XMRV replication
  11. Boule de feu

    Boule de feu Senior Member

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    In my case, I believe mycoplasma was the culprit.

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