"Tinfoil hat on or off".....Lol, gonna steal that one Leela. All my work in psych, never heard that one (although have seen lots of tin foil hats). Since we are speculating....Nope it's not too far out at all to consider a contaminated vaccine connection. The conspiracy belief pendulum can swing too far either direction from completely believable to way out there "nutsoid". IMO, the idea of a contaminated vaccine link to the current neuro-immune disease epidemic, lands just on the believable side of center. I think it's more difficult to believe there is no connection whatsoever. Your right about....The problem of contaminated vaccines is nothing new.....the timing with the spike in vaccine use and the explosion of neuro-immune disease....the bizarre political resistance to acceptance of these diseases....the locked UK archives on ME...etc, etc. It's kinda hard to rationally believe somethings not awry. As far as vaccine not explaining outbreaks? The contamination could have happened via vaccine years, even decades prior to disease onset and remained latent and controlled by our immune system until that certain immune insult with another infection, stress, vaccine, etc. It seems to me that since we have both sporadic and cluster outbreaks, the primary agent had to of been there prior to onset.....that is if we really have one sole cause of ME/CFS. A retrovirus makes the most sense to me. I did not have an infectious onset....I was very healthy when in 1993 my ME/CFS was triggered by the Hep B vaccine. But that vaccine was likely not contaminated because none of my peers got sick (although Hep B seems to be the most common vaccine trigger). But the vaccine certainly triggered something that was already there. Genetic predisposition doesn't always add up (ie. cluster outbreaks) either. So just what was it that was already there? Contaminated vaccine from childhood (ie. Polio)? Vertical transmission? Vector? Other latent infections?