Hi, I am new to all this! I have been unwell for about 3 years since doctors gave me a massive dose of Ramipril 3 weeks after having an episode of Takotsubo;I had been ridiculously fit and healthy until a stressful event triggered thi sone off heart episode. They then whacked me on evern higher dose of oxprenolol to try to reduce bp which I knew was only high due to ramipril reaction....and so on! They then took me off oxprenolol too quickly which gave me mitral valve proplapse-previous scans showed heart was in good nick! It took ages to get better from oxprenolol side effects, then I had dental hygienist appointment which left me with terrible aches, sharp pain in chest.....then months later chronic fatigue hit in big time. I am convinvced I have undiagnosed endocarditis on top of everything else but Docs will not listen. About Feb last year I was feeling best I had in ages then got a terrible cold - bed ridden for a week, laid up another week then began to improve. To help with this I used oregano oil which......gave me toxic side effects. Liver enzymes all fine, but I was feeling just as I had with oxprenolol. Should add at this point I can no longer tolerate any medication since the oxprenolol. My liver has been up and down since this, and I tried things like glutathione which I could take a year ago but can't tolerate now.....I got v excited reading about methylation and have had 2 days taking meythlfolate and b 12 and was weeing a normal colour for first time in ages and feeling much more me like.....but today the toxic liver symptoms are all coming back .I did well with coffee enemas until 3 weeks ago, but think as they triggered glutathione I went into over methylation with potassium issues for 5 days then back to feeling rubbish. I am concerned jhat my liver cannot tolerate methylation......any suggestions. Please. Life is such a struggle. I have 4 beauthiful children and I just want to be around for them. Thank you. And Happy New Year to all. I am in UK.