The protocolls of Rich and Freddd seem to work for some people, but as far as I see, most of them aren't fully healed yet. I think I found out why. During my research I came across the MTHFR polymorphism and I wondered if most of us have it. This polymorphism hinders the conversion from folic acid to 5-methyltetrahydrofolate(Metafolin, 5-MTHF). I also found studies about Folate receptor antibodies. So there are at least two conditions that result in low 5-MTHF. There is a product called Deplin, which is a high dose of Metafolin. It is marketed as a treatment against depression. It seems to do a great job. There are many enthusiastic articles about it on the net: http://www.drugs.com/comments/l-methylfolate/ Both Rich and Freddd suggest the use of Metafolin(5-methyltetrahydrofolic acid), but it's a small dosage in comparison to Deplin. So I wondered if a higher dosage might help. There is a guy called Dr. Smith who claims to treats CFS/ME successfully with Deplin and Methyl B12: http://www.youtube.com/watch?v=3KylT1Muvq8 Watch the video, you might be quite familiar with this theory I also found a thread from Karin: http://www.mecfsforums.com/index.php/topic,7009.0.html high dosages of folinic acid seem to help her. They found a study about folinic acid(5-MTHF precursor)which supports this hypothesis: yboldt14 takes 45mg of Deplin - which is a LOT - and it seems to work for him: http://forums.bettermedicine.com/sh...agnosed.?p=298013&highlight=Deplin#post298013 http://forums.bettermedicine.com/sh...agnosed.?p=298390&highlight=deplin#post298390 Karin and yboldt14 seem to have a problem with folate auto-antibodies. I started taking a high dose of Metafolin(15mg) for a few days and I definetly made improvements. My brain fog improved, my depressive mood is gone and I feel less fatigue. I feel quite happy at the moment. I don't want to promise too much, but it seems to help. The Van Konynenburg Hypothesis(thats how I call it ) made sense to me right at the beginning. Since yesterday I feel emotions, which I haven't felt for a long time Thank you Rich for leading me to this point!