In a nutshell Dr Ron Davis (and Drs Fluge / Mella) have found that "something in the serum" is causing ME/CFS cells to behave abnormally (hypometabolic) and that by putting the cells in healthy serum they become normal. Dr Robert Naviaux posits that the leaking of eATP by mitochondria is a cell danger single that leads to hypometabolism across a variety of chronic illnesses including ME/CFS and Autism (he famously hopes that the anti-purinergic drug suramin will "plug up the holes" preventing eATP from leaking and restoring normal metabolism). This may be too neat and simple a conclusion, but might that eATP be Dr Davis' mystery serum factor? Is eATP large enough to match Davis' filter size? Am I garbling Naviaux's CDR theory?