I would like to know what is your experience with corticosteroids. I think ME/CFS is a big beast so you need a big weapon against it and so I also tried prednisolone. I think my ME/CFS is pretty similar to an exacerbation of MS. Further, prednisolone has many substantial physiological effects and is effective against many diseases. See wiki or any standard textbook on molecular biology for more info. I started with 1mg of prednisolone, during a week I climbed up to 100mg, was taking 100mg for two weeks and then I went slowly down to zero. There was no effect on my ME/CFS. Side effects: negligible. My (perhaps flawed) conclusion: corticosteroids are of no help for me. What is your experience with corticosteroids?