1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
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AVIVA Semi-Finals: National ME/FM Action Network is competing for $100,000
The National ME/FM Action Network in Canada is competing for $100,000 for biomedical research of ME and FM in the Aviva Community Fund contest. With thanks to all who helped, they made it through the first round of voting into the Semi-Finals.
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Cortico

Discussion in 'General ME/CFS Discussion' started by lansbergen, Oct 25, 2013.

  1. lansbergen

    lansbergen Senior Member

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    I think I found why dexamethasone worsened the problem

    http://www.fasebj.org/content/16/1/61.full#sec-1

    Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells

    First, at the gene cluster level, our study shows a bidirectional action of GC, which are both immunostimulatory and immunosuppressive at the same time even for the inflammation cluster (12). They seemed to prime and enhance the innate immune response while repressing part of the adaptive immune response in a resting state. This suggests that GC help clear antigens by stimulating cell trafficking, scavenger systems, and matrix metalloproteinases while they halt cellular immune responses by inhibiting antigen presentation and T cell activation.
     
    Valentijn likes this.

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