International ME/CFS and FM Awareness Day is May 12: The World Will Know
Did you know that May 12 belongs to us? Lots of us are aware of this. We share the buzz on it amongst ourselves. We add blue ribbons to profile pictures. We raise our voices, join our hands, mount the few podiums available to us and tug at the sleeve of the rest of the world.
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Cortico

Discussion in 'General ME/CFS Discussion' started by lansbergen, Oct 25, 2013.

  1. lansbergen

    lansbergen Senior Member

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    I think I found why dexamethasone worsened the problem

    http://www.fasebj.org/content/16/1/61.full#sec-1

    Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells

    First, at the gene cluster level, our study shows a bidirectional action of GC, which are both immunostimulatory and immunosuppressive at the same time even for the inflammation cluster (12). They seemed to prime and enhance the innate immune response while repressing part of the adaptive immune response in a resting state. This suggests that GC help clear antigens by stimulating cell trafficking, scavenger systems, and matrix metalloproteinases while they halt cellular immune responses by inhibiting antigen presentation and T cell activation.
     
    Valentijn likes this.

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