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The Fable known as The PACE Trial
Graham, Janelle and Bob, have once again excelled themselves with their latest take on the 'poisoned apple' that was the PACE Trial...
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Cortico

Discussion in 'General ME/CFS Discussion' started by lansbergen, Oct 25, 2013.

  1. lansbergen

    lansbergen Senior Member

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    I think I found why dexamethasone worsened the problem

    http://www.fasebj.org/content/16/1/61.full#sec-1

    Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells

    First, at the gene cluster level, our study shows a bidirectional action of GC, which are both immunostimulatory and immunosuppressive at the same time even for the inflammation cluster (12). They seemed to prime and enhance the innate immune response while repressing part of the adaptive immune response in a resting state. This suggests that GC help clear antigens by stimulating cell trafficking, scavenger systems, and matrix metalloproteinases while they halt cellular immune responses by inhibiting antigen presentation and T cell activation.
    Valentijn likes this.

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