A New Decade of ME Research: The 11th Invest in ME International ME Conference 2016
Mark Berry presents the first in a series of articles on the 11th Invest in ME International ME Conference in London ...
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Discussion in 'General ME/CFS Discussion' started by lansbergen, Oct 25, 2013.

  1. lansbergen

    lansbergen Senior Member

    I think I found why dexamethasone worsened the problem


    Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells

    First, at the gene cluster level, our study shows a bidirectional action of GC, which are both immunostimulatory and immunosuppressive at the same time even for the inflammation cluster (12). They seemed to prime and enhance the innate immune response while repressing part of the adaptive immune response in a resting state. This suggests that GC help clear antigens by stimulating cell trafficking, scavenger systems, and matrix metalloproteinases while they halt cellular immune responses by inhibiting antigen presentation and T cell activation.
    Valentijn likes this.

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