Have you tried mifepristone by any chance yet?
I took a 250 mg test dose of mifepristone 9 days ago, and unfortunately developed substantial psychiatric side effects from it (including
extreme irritability for one day, then followed by some mild psychosis for about 5 days, then some depression). It's been a pretty unpleasant experience. I also found it much harder to get to sleep, and have been more tired than usual in these last 9 days.
However, I often tend to get neuropsychological side effects from drugs and sometimes supplements, so this type of response to a drug is not unusual for me. These psychiatric side effects may not occur in ME/CFS patients with more robust mental health.
I seem to be recovering from these side effects now; so if there are going to be any benefits from this single dose of ME/CFS, I would expect them to appear in the following days and weeks. I will keep you informed if any benefits appear.
I don't think I will be brave enough to take another dose of mifepristone after that unpleasant experience, except perhaps at a much lower dose. I previously tried a single 100 mg dose some months ago, and did not experience any side effects from that.