As the title says, copper supplementation makes me feel worse despite testing that shows I don't have Wilson's disease. My ceruloplasmin and serum copper levels are both on the low side repeatedly. Serum copper is within range, on the low side. Ceruloplasmin was below normal on two tests, and within range (on the low side) on one test. My liver function is normal except a slightly elevated ALP, but this is not really significant. My 24-urine copper was 18 mcg, which is well within the limits for a normal patient. Wilson's disease patients usually have 24 urinary copper levels of several hundred mcgs. I had an MRI done which the neurologist said was OK. I didn't get to thoroughly read the report, but I trust he would have told me if the radiologist saw anything. When I take copper, I feel worse - slightly nauseous, increase brain fog, more "out of it". My blood tests show that I should benefit from copper supplementation. I'm wondering if there is something to the whole "biounavailable copper" that some alternative med practitioners talk about. I don't know what to do - I don't think I'm going to continue with copper supplementation due to my symptoms, but it doesn't really make sense.