Hi All, I recently got my 23andme results, trying to figure out issues I've had since childhood, first a little about me: 32 old male, born and raised on the northeast coast of the US. Athletic build, 6'2", 178 lbs, avid gym workouts, healthy organic eating since I was 18. Kept abreast to most nutrition studies and findings over the last decade, raised vegetarian, however pescatarian for the last 12 years. Childhood sensitives to chemicals, bleaches, pine oils, household cleaners, just the smell would trigger discomfort, these have mostly subsided. Started getting gray hairs at around 6 -7 years old, however it never took over completely, have a nice salt/pepper look now 25 years later; perhaps this is a catalase / glutathione issue? Too much H2O2? Food allergies since onset of puberty (still trying to figure out the difference between sensitives and allergies), the following fruits/nuts/root veggies trigger closing of my air passage ways, minor swelling of the lips, itchy throat (all appear to be histamine type reactions): apples, peaches, pears, plums, dark cherries, almonds, hazelnuts, macadamia nuts, carrots, celery, guava, soy protein powder (tofu, edamame etc. is fine). All the foods listed above cause no issue if cooked/steamed, apparently that deactivates the protein triggering my allergies. From my research these could have started at youth due to overuse of antibiotics, excessive vaccinations, awful sugar/HFCS/hydrogenated fat laden diet common with 80's - 90's children. Perhaps candida, leaky gut type issues may have caused these food particles to pass out of the gut, triggering a lifelong immune response, not sure...But regardless how healthy I feel I am getting, they are still there. Currently on a gut-healing / powerful probiotic regimen (VSL3). I believe I have an issue with either way too much histamine production or histamine intolerance, perhaps histadelia. Mosquito bites swell immensely, always have itchy skin in the winter (saw a post where a study found that mice produce more histamine at the skin when there is low moisture in the air), pimples swell quite a bit more than I've seen with others etc. I have cystic acne in my teens, seemed to be a mixture of oily skin/hormones and my body pushing toxins from an awful diet through my skin, combined with anxiety during those formative years. I had lesions on the face, chest, and upper back. Would have adult acne now, but I keep a clean diet, supplement with cal / mag citrate, and food based multi, pharm grade fish oil, and 5000 IUs D3 daily. Eating a large green organic (kale/romaine) salad daily and mostly organic foods / produce / eggs helps. My skin scars fairly easily, I have a feeling the histamine and H2 production has something to do with my stomach acid and issues absorbing vitamin A and zinc, both crucial for skin tissue repair. I believe I have some level of ADD, get bored easily, learns quickly, overall have excelled quite a bit when I stay engaged and control my anxiety. I feel the anxiety and excitation is dopamine / epinephrine driven. Can appear very calm and collected when I out-think my anxiety, if that makes any sense. Can get tired easily in a low oxygen room, i.e. too many poeple in a room and doors closed, start yawning within 5-10 minutes. However, can perform quite a bit of work, heavy weight lifting, running (as long as I don't get bored), swimming etc After initially reading into MTHFR/glutathione/mB12/mfolate, I thought I had this issue for sure. but my anxiety/excitation/duration of acne make me think its something different. I really want to figure this out, my results from genetic genie are below, please let me know if you have any thoughts regarding the histamine, anxiety, tissue scarring etc.; any help is much appreciated: COMT V158M rs4680 AG +/- COMT H62H rs4633 CT +/- COMT P199P rs769224 GG -/- VDR Bsm rs1544410 CC -/- VDR Taq rs731236 AA +/+ MAO A R297R rs6323 G -/- ACAT1-02 rs3741049 GG -/- MTHFR C677T rs1801133 GG -/- MTHFR 03 P39P rs2066470 GG -/- MTHFR A1298C rs1801131 TT -/- MTR A2756G rs1805087 AG +/- MTRR A66G rs1801394 GG +/+ MTRR H595Y not found n/a not genotyped MTRR K350A rs162036 AA -/- MTRR R415T not found n/a not genotyped MTRR A664A rs1802059 GG -/- BHMT-02 rs567754 CT +/- BHMT-04 not found n/a not genotyped BHMT-08 rs651852 CC -/- AHCY-01 rs819147 CT +/- AHCY-02 not found n/a not genotyped AHCY-19 rs819171 CT +/- CBS C699T rs234706 AG +/- CBS A360A rs1801181 AG +/- Thanks!